Production of pharmaceutical grade [ 201 Tl]Thallous chloride using 30 MeV cyclotron.

Autor: Chattopadhyay S; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India. Electronic address: sankha@vecc.gov.in., Barua L; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Mahesh DG; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Ash S; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Mitra A; Radiopharmaceutical Laboratory, Board of Radiation and Isotope Technology, Navi Mumbai, India., Saha Das S; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Singha S; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Alam MN; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Madhusmita; Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India., Roy S; Medical Cyclotron Facility, Variable Energy Cyclotron Centre, Kolkata, India., Dhang P; Medical Cyclotron Facility, Variable Energy Cyclotron Centre, Kolkata, India., Jain M; Department of Nuclear Medicine, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2024 Feb; Vol. 204, pp. 111128. Date of Electronic Publication: 2023 Nov 30.
DOI: 10.1016/j.apradiso.2023.111128
Abstrakt: Multiple patient doses of [ 201 Tl]TlCl has been produced using electrodeposited enriched 203 Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 μA beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [ 201 Tl]TlCl. The produced [ 201 Tl]TlCl was used in coronary artery disease (CAD) patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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