Increased environmental microbial diversity reduces the disease risk of a mosquitocidal pathogen.
| Autor: | Kang Z; Hebei University, College of Life Sciences, Baoding, Hebei, China., Martinson VG; Department of Entomology, University of Georgia, Athens, Georgia, USA.; Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA., Wang Y; Department of Entomology, University of Georgia, Athens, Georgia, USA., Coon KL; Department of Entomology, University of Georgia, Athens, Georgia, USA.; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Valzania L; Department of Entomology, University of Georgia, Athens, Georgia, USA.; Institut Curie, Paris, France., Strand MR; Department of Entomology, University of Georgia, Athens, Georgia, USA. |
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| Jazyk: | angličtina |
| Zdroj: | MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0272623. Date of Electronic Publication: 2023 Dec 06. |
| DOI: | 10.1128/mbio.02726-23 |
| Abstrakt: | Importance: The host-specific microbiotas of animals can both reduce and increase disease risks from pathogens. In contrast, how environmental microbial communities affect pathogens is largely unexplored. Aquatic habitats are of interest because water enables environmental microbes to readily interact with animal pathogens. Here, we focused on mosquitoes, which are important disease vectors as terrestrial adults but are strictly aquatic as larvae. We identified a pathogen of mosquito larvae from the field as a strain of Chromobacterium haemolyticum . Comparative genomic analyses and functional assays indicate this strain and other Chromobacterium are mosquitocidal but are also opportunistic pathogens of other animals. We also identify a critical role for diversity of the environmental microbiota in disease risk. Our study characterizes both the virulence mechanisms of a pathogen and the role of the environmental microbiota in disease risk to an aquatic animal of significant importance to human health. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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