Gender-related differences in cardiometabolic risk factors and oxidative stress among prepubertal children with obesity.

Autor: Godinho N; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal., Morato M; Laboratório de Farmacologia, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto (FFUP), Porto, Portugal.; LAQV/REQUIMTE, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal., Albino-Teixeira A; MedInUP - Centro de Investigação Farmacológica e Inovação Medicamentosa da Universidade do Porto, Porto, Portugal.; Departamento de Biomedicina - Unidade de Farmacologia e Terapêutica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal., Caldas Afonso A; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Porto, Portugal.; Unidade de Nefrologia Pediátrica, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Sousa T; MedInUP - Centro de Investigação Farmacológica e Inovação Medicamentosa da Universidade do Porto, Porto, Portugal.; Departamento de Biomedicina - Unidade de Farmacologia e Terapêutica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal., Correia-Costa L; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Porto, Portugal.; Unidade de Nefrologia Pediátrica, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
Jazyk: angličtina
Zdroj: Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2023 Dec 07; Vol. 37 (1), pp. 42-51. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2024).
DOI: 10.1515/jpem-2023-0286
Abstrakt: Objectives: Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8-9 years old) from the generation XXI birth-cohort.
Methods: Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plasma total antioxidant status (P-TAS), serum myeloperoxidase (MPO), plasma and urinary nitrates and nitrites (P-NOX, U-NOX), and urinary hydrogen peroxide (U-H 2 O 2 ).
Results: Girls showed higher levels of total/non-HDL cholesterol, triglycerides, and insulin resistance (HOMA-IR) compared to boys. Notably, U-H 2 O 2 values were lower in girls. When stratifying by body mass index (BMI) and gender, both girls and boys exhibited higher MPO concentration and U-Isop values. Uric acid concentration was higher in overweight and obese girls than in normal weight girls, while no significant differences were observed among boys across BMI categories. Furthermore, U-NOX values differed only in boys, with higher levels observed in overweight and obese individuals compared to those with normal weight. Multivariate analysis, adjusted for age and BMI z-score, demonstrated inverse associations between U-H 2 O 2 and pulse wave velocity values, as well as between U-NOX and total or non-HDL cholesterol, exclusively in boys. In girls, a positive association between U-Isop and HOMA-IR values was observed.
Conclusions: In conclusion, gender differentially impacts oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors in prepubertal children. Prepubertal girls appear more susceptible to oxidative stress-induced metabolic dysfunction, while in boys, elevated levels of redox and nitric oxide bioavailability markers seem to provide protection against arterial stiffness and lipid homeostasis.
(© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze: MEDLINE
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