Transmembrane protein 14A protects glomerular filtration barrier integrity.

Autor: Khalil R; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Bonnemaijer JDD; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Kreutz R; Institute of Clinical Pharmacology and Toxicology, Charité - University Medicine, Berlin, Germany., Spaink HP; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands., Hogendoorn PCW; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Baelde HJ; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2023 Dec; Vol. 11 (23), pp. e15847.
DOI: 10.14814/phy2.15847
Abstrakt: Transmembrane protein 14A (TMEM14A) is a relatively unknown protein that is now identified to be required for maintaining the integrity of the glomerular filtration barrier. It is an integral transmembrane protein of 99 amino acids with three transmembrane domains. TMEM14A has been implied to suppress Bax-mediated apoptosis in other studies. Other than that, little is currently known of its function. Here, we show that its expression is diminished before onset of proteinuria in a spontaneously proteinuric rat model. Knocking down tmem14a mRNA translation results in proteinuria in zebrafish embryos without affecting tubular reabsorption. Also, it is primarily expressed by podocytes. Lastly, an increase in glomerular TMEM14A expression is exhibited in various proteinuric renal diseases. Overall, these results suggest that TMEM14A is a novel factor in the protective mechanisms of the nephron to maintain glomerular filtration barrier integrity.
(© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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