Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats.

Autor: Abdelmottaleb Moussa SA; Department of Biochemistry, National Research Centre, P.O. 12622 Cairo, Egypt., Aziz SW; Department of Biochemistry, National Research Centre, P.O. 12622 Cairo, Egypt., Abd El-Latif NA; Department of Biochemistry, National Research Centre, P.O. 12622 Cairo, Egypt., Bashandy SAE; Department of Pharmacology, National Research Centre, P.O. 12622 Cairo, Egypt., Elbaset MA; Department of Pharmacology, National Research Centre, P.O. 12622 Cairo, Egypt., Afifi SM; Pharmacognosy Department, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt., Esatbeyoglu T; Department of Food Development and Food Quality, Institute of Food Science and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30 30167 Hannover, Germany., El Toumy SA; Department of Tannins Chemistry, National Research Centre, P.O. 12622 Cairo, Egypt., Salib JY; Department of Tannins Chemistry, National Research Centre, P.O. 12622 Cairo, Egypt.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2023 Nov 27; Vol. 2023, pp. 8794214. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
DOI: 10.1155/2023/8794214
Abstrakt: Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable increment in HDL levels relative to the obese group ( p ≤ 0.05), was observed in rats receiving low and high doses of GB, accompanied by restoration of SOD activity and GSH levels. Rheological parameters of rats' blood have been studied over a wide range of shear rates (225-1875 s -1 ). A significant decrease in blood viscosity in rats who received low and high doses of GB extract was compatible with every shear rate compared to the control group. The shear stress values of the obese rats reduced appreciably ( p ≤ 0.05) in all values of shear rate (from 75 to 500 s -1 ) proportional to the control group, while in the groups that received low and high doses of GB extract, shear stress was restored to the control values. Finally, administration of GB extract significantly decreased yield stress and indices of whole blood aggregation, with an extremely substantial increment in flow rate, in rats given low or high doses of GB compared to obese ones. The result also showed a decrease in both the average raised osmotic fragility and the hemolysis rate in rats after supplementation with low and high doses of GB extract.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2023 Sherif A. Abdelmottaleb Moussa et al.)
Databáze: MEDLINE
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