Understanding the Radiation Dose Variability in Nasopharyngeal Cancer: An Organs-at-Risk Approach.

Autor:	Bin Sumaida A; Oncology/Radiation Oncology, Tawam Hospital, Al Ain, ARE., Shanbhag NM; Oncology/Palliative Care, Tawam Hospital, Al Ain, ARE.; Oncology/Radiation Oncology, Tawam Hospital, Al Ain, ARE.; Internal Medicine, United Arab Emirates University, Al Ain, ARE., Balaraj KS; Oncology, Tawam Hospital, Al Ain, ARE., Puratchipithan R; Radiation Oncology, Tawam Hospital, Al Ain, ARE., Hasnain SM; Radiation Oncology, Tawam Hospital, Al Ain, ARE., El-Koha O; Radiation Oncology, Tawam Hospital, Al Ain, ARE., Hussain A; Medical Physics, Tawam Hospital, Al Ain, ARE., Binz T; Radiotherapy Technology, Tawam Hospital, Al Ain, ARE., Rajendran VT; Medical Physics, Tawam Hospital, Al Ain, ARE., Nair RKR; Medical Physics, Tawam Hospital, Al Ain, ARE., Jaafar NH; Radiotherapy Technology, Tawam Hospital, Al Ain, ARE., Saleh M; Oncology, Tawam Hospital, Al Ain, ARE., Al Qawasmeh K; Nursing, Tawam Hospital, Al Ain, ARE.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Dec 03; Vol. 15 (12), pp. e49882. Date of Electronic Publication: 2023 Dec 03 (Print Publication: 2023).
DOI:	10.7759/cureus.49882
Abstrakt:	Objective This study aims to thoroughly assess the radiation dose distribution to critical organs in patients with nasopharyngeal carcinoma, focusing on the correlation between the radiation dosages for the various organs at risk (OARs) in nasopharyngeal cancer patients. Methods We meticulously analysed a dataset comprising 38 nasopharyngeal carcinoma patients, focusing on radiation dosages measured in Gray (Gy) and volumetric data in cubic centimetres (cc) of critical organs, including the lens, brainstem, spinal cord, optic nerve, optic chiasm, and cochlea. A detailed exploratory data analysis approach encompassed univariate, bivariate, and multivariate techniques. Results Our analysis revealed several key findings. The mean and median values across various dose measurements were closely aligned, indicating symmetrical distributions with minimal skewness. The histograms further corroborated this, showing evenly distributed dose values across different anatomical regions. The correlation matrix highlighted varying degrees of interrelationships between the doses, with some showing strong correlations while others exhibited minimal or no correlation. The 3D scatter plot provided a view of the multi-dimensional dose relationships, with a specific focus on the spinal cord, lens, and brainstem doses. The bivariate scatter plots revealed symmetrical distributions between the right and left lens doses and more complex relationships involving the brainstem and spinal cord, illustrating the intricacies of dose distribution in radiation therapy. Conclusion Our findings reveal distinct radiation exposure patterns to OARs of nasopharyngeal carcinoma. This research emphasises the need for tailored radiation therapy planning to achieve optimal clinical outcomes while safeguarding vital organs. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Bin Sumaida et al.)
Databáze:	MEDLINE
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