Aspects of the alternative host response to methacrylic acid containing biomaterials.

Autor: Ortaleza K; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Won SY; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Kinney SM; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada., Sefton MV; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2024 Aug; Vol. 112 (8), pp. 1276-1285. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1002/jbm.a.37652
Abstrakt: Methacrylic acid (MAA)-based biomaterials promote a vascularized host response without the addition of exogenous factors such as cells or growth factors. We presume that materials containing MAA favor an alternative foreign body response, rather than the conventional fibrotic response. Here, we characterize selected aspects of the response to two different forms of MAA-a coating, which can be used to prevascularize the subcutaneous tissue for subsequent therapeutic cell delivery or an injectable hydrogel, which can be used to vascularize and deliver cells simultaneously. We show that the MAA-coating quickly vascularized the subcutaneous space compared to an uncoated silicone tube, and after 14 days of prevascularization, the tissue surrounding the MAA-coated tube presented fewer immune cells than the uncoated control. We also compared the host response to a MAA-PEG (polyethylene glycol) hydrogel at day 1, with pancreatic islets in immune-compromised SCID/bg mice and immune-competent Balb/c mice. The Balb/c mouse presented a more inflammatory response with increased IFN-γ production as compared to the SCID/bg. Together with previously published data, this work contributes to a further understanding of tissue responses to a biomaterial in different forms as used for cell delivery.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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