Cytotoxicity evaluation of phytochemicals from stingless bee (Tetragonula biroi) propolis.

Autor: Ramadhan R; Division of Exploration and Synthesis of Bioactive Compounds (ESBC), CoE-University Research Center for Bio-Molecule Engineering (BIOME), Universitas Airlangga, Surabaya, 60115, Indonesia; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia., Syafrizal; Laboratory of Plant Systematic and Anatomy, Mathematics and Science Faculty, Mulawarman University, Samarinda, Indonesia., Kusuma IW; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia; Research Center for Medicine and Cosmetic from Tropical Rainforest Resources, Mulawarman University, Samarinda, Indonesia., Paramita S; Research Center for Medicine and Cosmetic from Tropical Rainforest Resources, Mulawarman University, Samarinda, Indonesia; Faculty of Medicine, Mulawarman University, Samarinda, Indonesia., Amen Y; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Kim YU; Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan, South Korea., Fatriasari W; Research Center for Biomass and Bioproducts, National Research and Innovation Agency, Bogor, 16911, Indonesia; Research Collaboration Center for Biomass-Based Nano Cosmetic, in Collaboration Mulawarman University and BRIN, Samarinda, East Kalimantan, 75119, Indonesia., Shimizu K; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan; Kyushu University Institute for Asian and Oceanian Studies, Fukuoka, Japan. Electronic address: shimizu@agr.kyushu-u.ac.jp., Arung ET; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia; Research Center for Medicine and Cosmetic from Tropical Rainforest Resources, Mulawarman University, Samarinda, Indonesia; Research Collaboration Center for Biomass-Based Nano Cosmetic, in Collaboration Mulawarman University and BRIN, Samarinda, East Kalimantan, 75119, Indonesia. Electronic address: tangkearung@yahoo.com.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Jan; Vol. 237, pp. 107352. Date of Electronic Publication: 2023 Dec 03.
DOI: 10.1016/j.toxicon.2023.107352
Abstrakt: Three prenylated flavonoids (1-3) were isolated from Tetragonula biroi propolis. The structures of the isolated compounds were characterized by NMR, IR, and UV spectroscopic and mass spectrometric analyses. The cytotoxicity activity of the crude extracts, fractions and the isolated compounds were established against four cell lines such as Caco-2, HeLa, MCF-7, and OVK-18. Among the tested compounds, compound 1 showed cytotoxicity activity against MCF-7 cell lines, whereas compound 2 showed good activity against Caco-2 and OVK-18 cell lines with IC 50 values of 14.73 and 14.44, respectively. Moreover, compound 3 exhibited strong activity against OVK-18 cell lines. These findings contribute to the phytochemical understanding of the T. biroi propolis, and their cytotoxicity effects for future pharmaceutical purposes.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Enos Tangke Arung reports financial support and equipment, drugs, or supplies were provided by Kementerian Pendidikan, Kebudayaan, Riset dan Teknologi of Indonesia in the scheme of the Excellence Basic Research/Kemendikbudristek (Grant no. 274/UN17.L1/HK/2023) for Enos Tangke Arung); and the Deputy of Research and Innovation, National Research and Innovation Agency (BRIN) for "Pusat Kolaboratif Riset Kosmetik Berteknologi Nano Berbasis Bio-massa" in the Fiscal Year 2023 (Grant number: 2534/II.7/HK.01.May 00, 2023).
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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