Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes.

Autor:	Şen Ö; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy., Emanet M; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy., Mazzuferi M; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy.; Department of Mechanical & Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy., Bartolucci M; Core Facilities-Clinical Proteomics and Metabolomics, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, Genova 16147, Italy., Catalano F; Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy., Prato M; Materials Characterization Facility, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy., Moscato S; Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy., Marino A; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy., De Pasquale D; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy., Pugliese G; Nanochemistry, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy., Bonaccorso F; BeDimensional SPA, Lungotorrente Secca 30R, Genova 16163, Italy.; Graphene Laboratories, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy., Pellegrini V; BeDimensional SPA, Lungotorrente Secca 30R, Genova 16163, Italy.; Graphene Laboratories, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy., Castillo AEDR; BeDimensional SPA, Lungotorrente Secca 30R, Genova 16163, Italy., Petretto A; Core Facilities-Clinical Proteomics and Metabolomics, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, Genova 16147, Italy., Ciofani G; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy.
Jazyk:	angličtina
Zdroj:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Dec 20; Vol. 15 (50), pp. 58260-58273. Date of Electronic Publication: 2023 Dec 05.
DOI:	10.1021/acsami.3c17097
Abstrakt:	Microglial cells play a critical role in glioblastoma multiforme (GBM) progression, which is considered a highly malignant brain cancer. The activation of microglia can either promote or inhibit GBM growth depending on the stage of the tumor development and on the microenvironment conditions. The current treatments for GBM have limited efficacy; therefore, there is an urgent need to develop novel and efficient strategies for drug delivery and targeting: in this context, a promising strategy consists of using nanoplatforms. This study investigates the microglial response and the therapeutic efficacy of dual-cell membrane-coated and doxorubicin-loaded hexagonal boron nitride nanoflakes tested on human microglia and GBM cells. Obtained results show promising therapeutic effects on glioma cells and an M2 microglia polarization, which refers to a specific phenotype or activation state that is associated with anti-inflammatory and tissue repair functions, highlighted through proteomic analysis.
Databáze:	MEDLINE
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