Natural and Synthetic Chalcones: Potential Impact on Breast Cancer.

Autor:	Dadi V; Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Technology, Visakhapatnam 530049, India., Malla RR; Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, School of Science, Gandhi Institute of Technology and Management (GITAM) (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India; Department of Biochemistry and Bioinformatics, School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India., Siragam S; Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Visakhapatnam 530049, India.
Jazyk:	angličtina
Zdroj:	Critical reviews in oncogenesis [Crit Rev Oncog] 2023; Vol. 28 (4), pp. 27-40.
DOI:	10.1615/CritRevOncog.2023049659
Abstrakt:	Chalcones are small molecules, naturally found in fruits and vegetables, and exhibit diverse pharmacological activities. They also possess anticancer activity against different tumors. They can be converted into numerous derivatives by modifying hydrogen moieties, enabling the exploration of their diverse anticancer potentials. The main aims are to provide valuable insights into the recent progress made in utilizing chalcones and their derivatives as agents against breast cancer while delivering their underlying molecular mechanisms of action. This review presents anticancer molecular mechanisms and signaling pathways modulated by chalcones. Furthermore, it helps in the understating of the precise mechanisms of action and specific molecular targets of chalcones and their synthetic derivatives for breast cancer treatment.
Databáze:	MEDLINE
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