Elevated BMI reduces the humoral response to SARS-CoV-2 infection.

Autor: Tong MZ; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Sng JD; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Carney M; School of Mathematics and Physics The University of Queensland St Lucia QLD Australia., Cooper L; Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia.; Immunity Program, Biomedicine Discovery Institute Monash University Clayton VIC Australia., Brown S; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Lineburg KE; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Infection and Inflammation Program QIMR Berghofer Medical Research Institute Herston QLD Australia., Chew KY; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Collins N; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Ignacio K; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Airey M; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Burr L; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Infection and Inflammation Program QIMR Berghofer Medical Research Institute Herston QLD Australia.; Department of Respiratory Medicine Mater Health Brisbane QLD Australia., Joyce BA; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia., Jayasinghe D; Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia.; Department of Biochemistry and Chemistry La Trobe Institute for Molecular Science, La Trobe University Bundoora VIC Australia., McMillan CL; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; Australian Infectious Diseases Research Centre The University of Queensland St Lucia QLD Australia., Muller DA; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; Australian Infectious Diseases Research Centre The University of Queensland St Lucia QLD Australia., Adhikari A; Department of Biochemistry and Chemistry La Trobe Institute for Molecular Science, La Trobe University Bundoora VIC Australia., Gallo LA; School of Health University of the Sunshine Coast Petrie QLD Australia., Dorey ES; Mater Research The University of Queensland South Brisbane QLD Australia., Barrett HL; Mater Research The University of Queensland South Brisbane QLD Australia.; University of New South Wales Medicine Kensington NSW Australia.; Obstetric Medicine Royal Hospital for Women Randwick NSW Australia., Gras S; Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia.; Department of Biochemistry and Chemistry La Trobe Institute for Molecular Science, La Trobe University Bundoora VIC Australia., Smith C; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Infection and Inflammation Program QIMR Berghofer Medical Research Institute Herston QLD Australia., Good-Jacobson K; Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia.; Immunity Program, Biomedicine Discovery Institute Monash University Clayton VIC Australia., Short KR; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.; Australian Infectious Diseases Research Centre The University of Queensland St Lucia QLD Australia.
Jazyk: angličtina
Zdroj: Clinical & translational immunology [Clin Transl Immunology] 2023 Dec 03; Vol. 12 (12), pp. e1476. Date of Electronic Publication: 2023 Dec 03 (Print Publication: 2023).
DOI: 10.1002/cti2.1476
Abstrakt: Objective: Class III obesity (body mass index [BMI] ≥ 40 kg m -2 ) significantly impairs the immune response to SARS-CoV-2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m -2 ) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.
Methods: We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI greater or less than 25 kg m -2 .
Results: Here, we show that an increased BMI (≥ 25 kg m -2 ), when accounting for age and sex differences, is associated with reduced antibody responses after SARS-CoV-2 infection. At 3 months of post-infection, an elevated BMI was associated with reduced antibody titres. At 13 months of post-infection, an elevated BMI was associated with reduced antibody avidity and a reduced percentage of spike-positive B cells. In contrast, no significant association was noted between a BMI ≥ 25 kg m -2 and humoral immunity to SARS-CoV-2 at 5 months of post-secondary vaccination.
Conclusions: Taken together, these data showed that elevated BMI is associated with an impaired humoral immune response to SARS-CoV-2 infection. The impairment of infection-induced immunity in individuals with a BMI ≥ 25 kg m -2 suggests an added impetus for vaccination rather than relying on infection-induced immunity.
Competing Interests: KRS is a consultant for Sanofi, Roche and NovoNordisk. The opinions and data presented in this manuscript are of the authors and are independent of these relationships. Other authors declare no competing interests.
(© 2023 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)
Databáze: MEDLINE
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