A Retrospective Analysis of Hyperlipidemia and COVID-19 Outcomes Investigated in a Rural Midwestern Population.

Autor:	Steffes R; Department of Osteopathic Medicine, Kansas City University, Kansas City, USA., Christensen S; Department of Osteopathic Medicine, Kansas City University, Joplin, USA., Schreck L; Department of Osteopathic Medicine, Kansas City University, Joplin, USA., Beyersdorfer N; Department of Primary Care, College of Medicine, Kansas City University, Joplin, USA., Goade DS; Department of Pharmacy, Freeman Health System, Joplin, USA., Johnson K; Department of Mathematics, Missouri Southern State University, Joplin, USA., Stahl G; College of Medicine, Kansas City University, Joplin, USA., Ford N; College of Medicine, Kansas City University, Joplin, USA., Arnce RD; Department of Osteopathic Medicine, Kansas City University, Joplin, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Nov 03; Vol. 15 (11), pp. e48211. Date of Electronic Publication: 2023 Nov 03 (Print Publication: 2023).
DOI:	10.7759/cureus.48211
Abstrakt:	Background COVID-19 is a respiratory disease caused by SARS-CoV-2, a coronavirus discovered in 2019. Its impact on the world continues to be studied due to the significant death toll of the disease. As the COVID-19 pandemic remains ongoing, examining the association of COVID-19 with comorbidities and resulting mortality is necessary. This study focuses on population health outcomes with COVID-19 infection and hyperlipidemia (total cholesterol greater than or equal to 200 mg/dL) as a comorbidity, including potential associations with age and sex. Methods As a retrospective analytical study, patients were divided into three populations based on COVID-19 and/or hyperlipidemia based on the International Classification of Diseases, Tenth Edition (ICD-10) codes reported in the electronic medical record system at Freeman Health System (FHS) in Southwest Missouri from April 1, 2020, to December 31, 2021. Wald's methods and two sample proportion summary hypotheses with confidence intervals (CIs) were used for comparison. The populations were subdivided and analyzed for age and sex differences. Results Patients with both COVID-19 and hyperlipidemia had a higher mortality rate than patients with COVID-19 and without hyperlipidemia and patients with hyperlipidemia and without COVID-19; patients with COVID-19 and without hyperlipidemia had a higher mortality rate than patients with hyperlipidemia and without COVID-19. All comparisons across these populations were statistically significant (p-value < 0.05). While increased age was associated with increased mortality in all groups, sex was not predictive in this regard. Conclusion Our study provides insights into variables affecting COVID-19 outcomes in a rural Midwestern population by showing how the comorbidity hyperlipidemia contributes to increased mortality. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Steffes et al.)
Databáze:	MEDLINE
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