Effect of camel milk on lipid profile among patients with diabetes: a systematic review, meta-analysis, and meta-regression of randomized controlled trials.

Autor:	Khalid N; Department of Nutrition and Dietetics, Bahrain Defense Force Royal Medical Services Hospital, Riffa, Bahrain., Abdelrahim DN; Sharjah Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE., Hanach N; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, 6211 LM, The Netherlands., AlKurd R; Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan., Khan M; Nutrition Studies Research Group, Department of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.; Primary Care, NHS Northwest London, TW3 3EB, London, UK., Mahrous L; Department of Health Sciences / Track of Clinical Nutrition, College of Health and Rehabilitation, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Radwan H; Department of Clinical Nutrition and Dietetics, College of Health Sciences, Sharjah Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE., Naja F; Department of Clinical Nutrition and Dietetics, College of Health Sciences, Sharjah Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE., Madkour M; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, UAE., Obaideen K; Center for Advanced Materials Research, University of Sharjah, Sharjah, UAE., Khraiwesh H; Department of Nutrition and Food Processing, College of Agricultural Technology, Al-Balqa University, Salt, Jordan., Faris M; Department of Clinical Nutrition and Dietetics, College of Health Sciences, Sharjah Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE. mfaris@sharjah.ac.ae.
Jazyk:	angličtina
Zdroj:	BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Dec 04; Vol. 23 (1), pp. 438. Date of Electronic Publication: 2023 Dec 04.
DOI:	10.1186/s12906-023-04257-5
Abstrakt:	The effects of camel milk (CM) intake on lipid profile among patients with diabetes remain controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to calculate the effect size of CM intake on blood lipids among patients with type 1 (T1D) and type 2 (T2D) diabetes. We searched nine databases from inception until December 31, 2022, to identify relevant RCTs. Effect sizes for total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) were calculated and expressed using mean differences (MD) and confidence intervals (CI). Of 4,054 retrieved articles, 10 RCTs (a total of 347 participants aged 8-70 years, 60.5% male) were eligible for inclusion. The pooled results from a random-effects model showed statistically significant decreases in TC (MD - 21.69, 95% CI: 41.05, - 2.33; p = 0.03; I 2 =99%), TG (MD - 19.79, 95% CI: -36.16, - 3.42; p=0.02, I 2 =99%), and LDL (MD -11.92, CI: -20.57, -3.26; p = 0.007, I 2 =88%), and a significant increase in HDL (MD 10.37, 95% CI, 1.90, 18.84; p=0.02, I 2 =95%) in patients with diabetes supplemented with CM compared with usual care alone. Subgroup analysis revealed that only long-term interventions (> 6 months) elicited a significant reduction in TC levels and TG levels. Consumption of fresh CM by patients with diabetes resulted in significant reductions in TC, TG, and LDL levels, while showing a significant increase in HDL levels. Patients with T1D elicited a more beneficial effect in lowering TC, LDL, and TG levels and in increasing HDL levels than their corresponding partners with T2D. In conclusion, long-term consumption of CM for patients with diabetes, especially those with T1D, could be a useful adjuvant therapy to improve lipid profile alongside prescribed medications. However, the high heterogeneity in the included studies suggests that more RCTs with larger sample sizes and longer intervention durations are required to improve the robustness of the available evidence. (© 2023. The Author(s).)
Databáze:	MEDLINE
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