Theory of mind in mild cognitive impairment and Parkinson's disease: The role of memory impairment.

Autor: Maggi G; Department of Psychology, University of Campania 'Luigi Vanvitelli,' Viale Ellittico, 31, 81100, Caserta, Italy. gianpaolo.maggi@unicampania.it., Giacobbe C; Department of Psychology, University of Campania 'Luigi Vanvitelli,' Viale Ellittico, 31, 81100, Caserta, Italy., Vitale C; Institute of Diagnosis and Health, IDC-Hermitage Capodimonte, Naples, Italy.; Department of Motor Sciences and Wellness, University 'Parthenope, Naples, Italy., Amboni M; Institute of Diagnosis and Health, IDC-Hermitage Capodimonte, Naples, Italy.; Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy., Obeso I; HM Hospitales - Centro Integral de Neurociencias AC HM CINAC, Hospital Universitario HM Puerta del Sur, HM Hospitales, Avda. Carlos V, 70. 28938, Móstoles, Madrid, Spain. i.obesomartin@gmail.com.; Department of Psychobiology and Methods on Behavioural Sciences, Complutense University of Madrid, Madrid, Spain. i.obesomartin@gmail.com., Santangelo G; Department of Psychology, University of Campania 'Luigi Vanvitelli,' Viale Ellittico, 31, 81100, Caserta, Italy. gabriella.santangelo@unicampania.it.
Jazyk: angličtina
Zdroj: Cognitive, affective & behavioral neuroscience [Cogn Affect Behav Neurosci] 2024 Feb; Vol. 24 (1), pp. 156-170. Date of Electronic Publication: 2023 Dec 04.
DOI: 10.3758/s13415-023-01142-z
Abstrakt: Background: Social cognition is impaired in Parkinson's disease (PD). Whether social cognitive impairment (iSC) is a by-product of the underlying cognitive deficits in PD or a process independent of cognitive status is unknown. To this end, the present study was designed to investigate the weight of specific cognitive deficits in social cognition, considering different mild cognitive impairment subtypes of PD (PD-MCI).
Methods: Fifty-eight PD patients underwent a neuropsychological battery assessing executive functions, memory, language, and visuospatial domains, together with social cognitive tests focused on theory of mind (ToM). Patients were divided into subgroups according to their clinical cognitive status: amnestic PD-MCI (PD-aMCI, n = 18), non-amnestic PD-MCI (PD-naMCI, n = 16), and cognitively unimpaired (PD-CU, n = 24). Composite scores for cognitive and social domains were computed to perform mediation analyses.
Results: Memory and language impairments mediated the effect of executive functioning in social cognitive deficits in PD patients. Dividing by MCI subgroups, iSC occurred more frequently in PD-aMCI (77.8%) than in PD-naMCI (18.8%) and PD-CU (8.3%). Moreover, PD-aMCI performed worse than PD-CU in all social cognitive measures, whereas PD-naMCI performed worse than PD-CU in only one subtype of the affective and cognitive ToM tests.
Conclusions: Our findings suggest that ToM impairment in PD can be explained by memory dysfunction that mediates executive control. ToM downsides in the amnesic forms of PD-MCI may suggest that subtle changes in social cognition could partly explain future transitions into dementia. Hence, the evaluation of social cognition in PD is critical to characterize a possible behavioral marker of cognitive decline.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: