| Autor: |
Ortiz-Rivero E; Nanomaterials for Bioimaging Group, Departamento de Física de Materiales, & Instituto de materiales Nicolás Cabrera & Institute for Advanced Research in Chemical Sciences,, Universidad Autónoma de Madrid, Madrid 28049, Spain., Orozco-Barrera S; Universidad de Granada, Nanoparticles Trapping Laboratory, Research Unit Modeling Nature (MNat) and Department of Applied Physics, 18071 Granada, Spain., Chatterjee H; Universidad de Granada, Nanoparticles Trapping Laboratory, Research Unit Modeling Nature (MNat) and Department of Applied Physics, 18071 Granada, Spain., González-Gómez CD; Universidad de Granada, Nanoparticles Trapping Laboratory, Research Unit Modeling Nature (MNat) and Department of Applied Physics, 18071 Granada, Spain.; Universidad de Málaga, Department of Applied Physics II, 29071 Málaga, Spain., Caro C; Biomedical Magnetic Resonance Laboratory-BMRL, Andalusian Public Foundation Progress and Health-FPS, 41092 Sevilla, Spain.; Biomedical Research Institute of Málaga and Nanomedicine Platform (IBIMA-BIONAND Platform), University of Málaga, C/Severo Ochoa 35, 29590 Málaga, Spain., García-Martín ML; Biomedical Magnetic Resonance Laboratory-BMRL, Andalusian Public Foundation Progress and Health-FPS, 41092 Sevilla, Spain.; Biomedical Research Institute of Málaga and Nanomedicine Platform (IBIMA-BIONAND Platform), University of Málaga, C/Severo Ochoa 35, 29590 Málaga, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 28029 Madrid, Spain., González PH; Nanomaterials for Bioimaging Group, Departamento de Física de Materiales, & Instituto de materiales Nicolás Cabrera & Institute for Advanced Research in Chemical Sciences,, Universidad Autónoma de Madrid, Madrid 28049, Spain., Rica RA; Universidad de Granada, Nanoparticles Trapping Laboratory, Research Unit Modeling Nature (MNat) and Department of Applied Physics, 18071 Granada, Spain., Gámez F; Department of Physical Chemistry, Universidad Complutense de Madrid, 28040 Madrid, Spain. |
| Abstrakt: |
Anisotropic hybrid nanostructures stand out as promising therapeutic agents in photothermal conversion-based treatments. Accordingly, understanding local heat generation mediated by light-to-heat conversion of absorbing multicomponent nanoparticles at the single-particle level has forthwith become a subject of broad and current interest. Nonetheless, evaluating reliable temperature profiles around a single trapped nanoparticle is challenging from all of the experimental, computational, and fundamental viewpoints. Committed to filling this gap, the heat generation of an anisotropic hybrid nanostructure is explored by means of two different experimental approaches from which the local temperature is measured in a direct or indirect way, all in the context of hot Brownian motion theory. The results were compared with analytical results supported by the numerical computation of the wavelength-dependent absorption efficiencies in the discrete dipole approximation for scattering calculations, which has been extended to inhomogeneous nanostructures. Overall, we provide a consistent and comprehensive view of the heat generation in optical traps of highly absorbing particles from the viewpoint of the hot Brownian motion theory. |
