Different doses of imeglimin for management of type 2 diabetes mellitus: a systematic review, meta-analysis, and meta-regression of randomized clinical trials.

Autor: Permana H; Division of Endocrinology, Metabolic Disorders and Diabetes, Department of Internal Medicine, Padjadjaran University, Bandung, West Java, Indonesia., Soetedjo NNM; Division of Endocrinology, Metabolic Disorders and Diabetes, Department of Internal Medicine, Padjadjaran University, Bandung, West Java, Indonesia., Yanto TA; Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Karawaci, Tangerang, Indonesia., Tendean M; Division of Endocrinology, Metabolic Disorders and Diabetes, Department of Internal Medicine, Padjadjaran University, Bandung, West Java, Indonesia., Hariyanto TI; Faculty of Medicine, Pelita Harapan University, Karawaci, Tangerang, Indonesia., Suastika K; Division of Endocrinology, Metabolic Disorders and Diabetes, Department of Internal Medicine, Udayana University, Denpasar, Bali, Indonesia.
Jazyk: angličtina
Zdroj: Expert review of endocrinology & metabolism [Expert Rev Endocrinol Metab] 2024 Jan-May; Vol. 19 (1), pp. 89-98. Date of Electronic Publication: 2024 Jan 01.
DOI: 10.1080/17446651.2023.2290488
Abstrakt: Background: A new medication for type 2 diabetes mellitus (T2DM) called imeglimin can target all three organs involved in the pathogenesis of DM, namely the liver, skeletal muscles, and pancreas. This research seeks to examine the most efficacious and safe dose of imeglimin for the management of T2DM.
Research Design and Methods: Using particular keywords, we searched the CENTRAL, Medline, Scopus, and ClinicalTrials.gov databases for pertinent literature. The results of continuous variables were pooled into the mean difference (MD) and dichotomous variables into odds ratio (OR) along with their 95% confidence intervals (95% CI) using fixed-effect models.
Results: Our pooled analysis revealed that imeglimin 1000 mg twice daily [MD -0.90% p  < 0.00001] and 1500 mg twice daily [MD -0.84% p  = 0.0003] as monotherapy was associated with a higher reduction in the HbA 1c compared to placebo. This superiority was still maintained when given as combination therapy. Regrettably, there was an observed escalation in gastrointestinal AEs as the dosage of imeglimin was raised, despite the absence of a corresponding improvement in its efficacy in decreasing HbA 1c levels.
Conclusions: Our study suggests that imeglimin 1000 mg twice daily may offer the most optimum therapeutic effects for glycemic control without compromising its safety profiles.
Databáze: MEDLINE