G6PDH as a key immunometabolic and redox trigger in arthropods.

Autor:	Moraes B; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil., Martins R; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil., Lopes C; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil., Martins R; Programa de Computação Científica, Instituto Oswaldo Cruz, IOC, Rio de Janeiro, Brazil., Arcanjo A; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil., Nascimento J; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil., Konnai S; Laboratory of Infectious Diseases, Hokkaido University, Sapporo, Japan., da Silva Vaz I Jr; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil.; Centro de Biotecnologia and Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Logullo C; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular-INCT, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2023 Nov 17; Vol. 14, pp. 1287090. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).
DOI:	10.3389/fphys.2023.1287090
Abstrakt:	The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose homeostasis and the pentose phosphate pathway (PPP), being also involved in redox metabolism. The PPP is an important metabolic pathway that produces ribose and nicotinamide adenine dinucleotide phosphate (NADPH), which are essential for several physiologic and biochemical processes, such as the synthesis of fatty acids and nucleic acids. As a rate-limiting step in PPP, G6PDH is a highly conserved enzyme and its deficiency can lead to severe consequences for the organism, in particular for cell growth. Insufficient G6PDH activity can lead to cell growth arrest, impaired embryonic development, as well as a reduction in insulin sensitivity, inflammation, diabetes, and hypertension. While research on G6PDH and PPP has historically focused on mammalian models, particularly human disorders, recent studies have shed light on the regulation of this enzyme in arthropods, where new functions were discovered. This review will discuss the role of arthropod G6PDH in regulating redox homeostasis and immunometabolism and explore potential avenues for further research on this enzyme in various metabolic adaptations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor FG declared a shared affiliation with the author RM at the time of review. (Copyright © 2023 Moraes, Martins, Lopes, Martins, Arcanjo, Nascimento, Konnai, da Silva Vaz and Logullo.)
Databáze:	MEDLINE
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