Analysis of prevalence of adverse events connected with anti-tuberculosis drugs during pregnancy: A meta-analysis.

Autor:	Wu D; Department of Obstetrics, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China., Li X; Department of Obstetrics, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China., Wan H; Department of Obstetrics, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China., Shami A; Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia., Alhassan HH; Department of Clinical Laboratory Science, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia., Al-Enazi MM; Department of Medical Laboratory Science, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Mir Najib Ullah SN; Department of Pharmacognosy, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia., Nashwan AJ; Hamad Medical Corporation, Doha, Qatar., Khan S; Department of Medical Lab Technology, Indian Institute of Health and Technology (IIHT), Deoband, 247554, Saharanpur, UP, India.; Department of Health Sciences, Novel Global Community Educational Foundation, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Nov 23; Vol. 9 (12), pp. e22786. Date of Electronic Publication: 2023 Nov 23 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e22786
Abstrakt:	Background: Mycobacterium tuberculosis infection is transmitted among humans via airborne droplets. The drugs used in the initial treatment regimen for tuberculosis (TB) cross the placenta, raising some concerns regarding their safety during pregnancy may provide a more valid approach for evaluating the relative influence of various risk factors. Adverse events of anti-tuberculous (anti-TB) drug during pregnancy remain uncertain and controversial issues. Methods: We performed a systematic analysis to study the adverse events connected with anti-TB drugs usage during pregnancy. The risk of bias in the included studies was assessed using the Cochrane Collaboration criteria. Interstudy heterogeneity was assessed via Cochran's test. Assuming heterogeneity, a random-effects model was applied. Outcomes were pooled using the inverse variance method. Besides, a funnel plot was created to assess publication bias. We used Egger's linear regression test of funnel plot asymmetry, modified to accommodate inter-study heterogeneity. Effect estimates and confidence intervals for all studies were depicted on a forest plot. Results: The prevalence of total adverse events for all anti-TB drugs was 25.9 %. According to the drug category, the prevalence of total adverse events was 50 % for ethambutol, 32.6 % for the six-month directly observed treatment short-course (DOTS), 31.4 % for the nine-month DOTS, and 13.7 % for isoniazid. Conclusions: There is a high rate of reported adverse events associated with anti-TB drugs usage during pregnancy. We concluded that more high-quality clinical studies and research works are needed to reach a conclusive decision on the safety of the treatment of TB among pregnant women. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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