Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion.

Autor:	Plitt MH; Department of Neurobiology, Stanford University School of Medicine; Stanford, CA, USA.; These authors contributed equally to this work.; Present address: Department of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, USA., Kaganovsky K; Department of Neurosurgery, Stanford University School of Medicine; Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine; Stanford, CA, USA.; These authors contributed equally to this work.; Present address: Department of Psychiatry and Behavioral Sciences, Center for Sleep Sciences and Medicine, Stanford University School of Medicine; Stanford, CA, USA., Südhof TC; Department of Neurosurgery, Stanford University School of Medicine; Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine; Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine; Stanford, CA, USA., Giocomo LM; Department of Neurobiology, Stanford University School of Medicine; Stanford, CA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 21. Date of Electronic Publication: 2023 Nov 21.
DOI:	10.1101/2023.11.20.567978
Abstrakt:	Rapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component of synaptic plasticity. However, it is unknown how this process supports specific neural computations during behavior. To bridge this gap, we combined conditional genetic deletion of a component of the postsynaptic membrane fusion machinery, Syntaxin3 (Stx3), in hippocampal CA1 neurons of mice with population in vivo calcium imaging. This approach revealed that Stx3 is necessary for forming the neural dynamics that support novelty processing, spatial reward memory and offline memory consolidation. In contrast, CA1 Stx3 was dispensable for maintaining aspects of the neural code that exist presynaptic to CA1 such as representations of context and space. Thus, manipulating postsynaptic membrane fusion identified computations that specifically require synaptic restructuring via membrane trafficking in CA1 and distinguished them from neural representation that could be inherited from upstream brain regions or learned through other mechanisms. Competing Interests: Declarations of Interests The authors declare no competing interests.
Databáze:	MEDLINE
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