Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models.

Autor: Mthembu SXH; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town, 7505, South Africa.; Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho, 2735, South Africa., Mazibuko-Mbeje SE; Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho, 2735, South Africa.; Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy., Ziqubu K; Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho, 2735, South Africa., Muvhulawa N; Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho, 2735, South Africa., Marcheggiani F; Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy., Cirilli I; Department of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, 60131, Ancona, Italy., Nkambule BB; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa., Muller CJF; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town, 7505, South Africa.; Centre for Cardiometabolic Research Africa (CARMA), Division of Medical Physiology, Stellenbosch University, Tygerberg, Cape Town, 7505, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, Empangeni, 3886, South Africa., Basson AK; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, Empangeni, 3886, South Africa., Tiano L; Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy., Dludla PV; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town, 7505, South Africa. pdludla@mrc.ac.za.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, Empangeni, 3886, South Africa. pdludla@mrc.ac.za.; Cochrane South Africa, South African Medical Research Council, Tygerberg, 7505, South Africa. pdludla@mrc.ac.za.
Jazyk: angličtina
Zdroj: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Mar; Vol. 476 (3), pp. 283-293. Date of Electronic Publication: 2023 Dec 04.
DOI: 10.1007/s00424-023-02890-0
Abstrakt: High-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to HFD feeding. Here, some of the major electronic databases like PubMed, Embase, and Web of Science were accessed to update and critically discuss information on the potential role of PGC-1α during metabolic adaptations within the skeletal muscle in response to HFD feeding in rodents. In fact, available evidence suggests that partial exposure to HFD feeding (potentially during the early stages of disease development) is associated with impaired metabolic adaptations within the skeletal muscle, including mitochondrial dysfunction and reduced insulin sensitivity. In terms of implicated molecular mechanisms, these negative effects are partially associated with reduced activity of PGC-1α, together with the phosphorylation of protein kinase B and altered expression of genes involving nuclear respiratory factor 1 and mitochondrial transcription factor A within the skeletal muscle. Notably, metabolic abnormalities observed with chronic exposure to HFD (likely during the late stages of disease development) may potentially occur independently of PGC-1α regulation within the muscle of rodents. Summarized evidence suggests the causal relationship between PGC-1α regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development. It further indicates that prominent interventions like caloric restriction and physical exercise may affect PGC-1α regulation during effective modulation of metabolic processes.
(© 2023. The Author(s).)
Databáze: MEDLINE
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