miR-221 and Parkinson's disease: A biomarker with therapeutic potential.

Autor: Zamanian MY; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Physiology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran., Ivraghi MS; School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran., Gupta R; Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India., Prasad KDV; Symbiosis Institute of Business Management (SIBM), Hyderabad, India.; Symbiosis International (Deemed University) (SIU), Hyderabad, Telangana, India., Alsaab HO; Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia., Hussien BM; Medical Laboratory Technology Department, College of Medical Technology, Islamic University, Najaf, Iraq., Ahmed H; Medical Technical College, Al-Farahidi University, Baghdad, Iraq., Ramadan MF; College of Dentistry, Al-Ayen University, Thi-Qar, Iraq., Golmohammadi M; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nikbakht N; Department of Physical Medicine and Rehabilitation, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran., Oz T; Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland., Kujawska M; Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2024 Jan; Vol. 59 (2), pp. 283-297. Date of Electronic Publication: 2023 Dec 03.
DOI: 10.1111/ejn.16207
Abstrakt: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to various motor and non-motor symptoms. Several cellular and molecular mechanisms such as alpha-synuclein (α-syn) accumulation, mitochondrial dysfunction, oxidative stress and neuroinflammation are involved in the pathogenesis of this disease. MicroRNAs (miRNAs) play important roles in post-transcriptional gene regulation. They are typically about 21-25 nucleotides in length and are involved in the regulation of gene expression by binding to the messenger RNA (mRNA) molecules. miRNAs like miR-221 play important roles in various biological processes, including development, cell proliferation, differentiation and apoptosis. miR-221 promotes neuronal survival against oxidative stress and neurite outgrowth and neuronal differentiation. Additionally, the role of miR-221 in PD has been investigated in several studies. According to the results of these studies, (1) miR-221 protects PC12 cells against oxidative stress induced by 6-hydroxydopamine; (2) miR-221 prevents Bax/caspase-3 signalling activation by stopping Bim; (3) miR-221 has moderate predictive power for PD; (4) miR-221 directly targets PTEN, and PTEN over-expression eliminates the protective action of miR-221 on p-AKT expression in PC12 cells; and (5) miRNA-221 controls cell viability and apoptosis by manipulating the Akt signalling pathway in PD. This review study suggested that miR-221 has the potential to be used as a clinical biomarker for PD diagnosis and stage assignment.
(© 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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