Stenotrophomonas maltophilia outbreak originating from a pull-out faucet in a pediatric intensive care unit in Turkey: Insights from clinical records and molecular typing.

Autor: Yashar M; Department of School of Medicine, Istanbul Medipol University, School of Medicine, Istanbul, Turkey. Electronic address: meltem.yasar@std.medipol.edu.tr., Basarir KE; Department of International School of Medicine, Istanbul Medipol University, International School of Medicine, Istanbul, Turkey., Tanriverdi ES; Department of Clinical Microbiology, Malatya Training and Research Hospital, Clinical Microbiology Laboratory, Malatya, Turkey., Celep S; Istanbul Medipol Mega Hospital, Department of Clinical Microbiology, Istanbul, Turkey., Sirekbasan L; Istanbul Medipol Mega Hospital, Department of Clinical Microbiology, Istanbul, Turkey., Rakici E; Department of Clinical Microbiology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkey., Ejder N; Department of Clinical Microbiology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkey., Musellim E; Department of Infection control Unit, Istanbul Medipol Mega Hospital, Infection Control Unit, Istanbul, Turkey., Cicek AC; Istanbul Medipol University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey., Yilmaz M; Istanbul Medipol University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: American journal of infection control [Am J Infect Control] 2024 May; Vol. 52 (5), pp. 605-610. Date of Electronic Publication: 2023 Dec 02.
DOI: 10.1016/j.ajic.2023.11.018
Abstrakt: Background: Nosocomial Stenotrophomonas maltophilia-related cases are rising and pose a threat to immunocompromised patients. Twelve patients from our pediatric intensive care unit (PICU) presented with S maltophilia-associated bloodstream infection.
Methods: This outbreak investigation includes 12 patients from PICU between the ages of 2 months and 4 years (mean 16 months, 7 male). To identify the origin, samples from all possible sources throughout the hospital were collected and ran through DNA isolation and Pulse Field Gel Electrophoresis.
Results: 120 samples were collected during the outbreak. 31 samples (26%) were positive for S maltophilia. 30 S maltophilia isolates were analyzed, 10 different genotypes were identified. Clustering isolates were grouped into 3 different clusters (tolerance and optimization 1.0, cutoff 90%). The largest cluster was genotype 1, which included 19 isolates, those belong to patients' samples and a sample from a pull-out faucet inside the PICU. The Pull-out faucet was the origin of the bloodstream infection.
Discussion: Pull-out faucets allow biofilm production, due its structure. Pulse Field Gel Electrophoresis identifies the transmission dynamics of the outbreak, with its high discriminatory power.
Conclusions: Water sources should be monitored on a regular basis. Pull-out faucets enable bacterial overgrowth; therefore, we recommend water surveillance during outbreak investigations.
(Copyright © 2023 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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