Amyloidosis and Considerations for the Hand Surgeon.

Autor:	Brown CR; Department of Orthopedic Surgery, University of Virginia, Charlottesville, VA. Electronic address: chelseabrownmd@gmail.com., Bergin JD; Department of Cardiology, University of Virginia, Charlottesville, VA., Deal DN; Department of Orthopedic Surgery, University of Virginia, Charlottesville, VA.
Jazyk:	angličtina
Zdroj:	The Journal of hand surgery [J Hand Surg Am] 2024 Mar; Vol. 49 (3), pp. 260-266. Date of Electronic Publication: 2023 Dec 02.
DOI:	10.1016/j.jhsa.2023.10.013
Abstrakt:	Amyloidosis can lead to cardiac, renal, and other multiorgan failure. New treatments have become available that can prolong survival but rely on early diagnosis. Manifestations of amyloidosis in hand surgery include carpal tunnel syndrome, trigger finger, peripheral neuropathy, and spontaneous distal biceps rupture. Often, these can predate systemic amyloidosis, offering hand surgeons an opportunity to diagnose patients with amyloidosis before systemic disease, refer them for treatment, and potentially alter disease course and prolong survival. In this review, we describe the pathophysiology and two most common subtypes of amyloidosis seen by hand surgeons. We provide guidance on biopsy practices and referral for patients with amyloidosis. Lastly, we provide a brief overview of the treatments for amyloidosis and their effect on disease course. (Copyright © 2024 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu