Placebo and nocebo in the treatment of migraine: How much does real world effectiveness depend on contextual effects?

Autor: Basedau H; Department of Systems Neuroscience, University Medical Center Hamburg- Eppendorf, Hamburg, Germany., Ornello R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Matteis E; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Davaasuren B; Department of Neurology, State Special Servant Hospital of Mongolia, Ulaanbaatar, Mongolia., Kadyrova B; Department of Special Clinical Disciplines, International School of Medicine of International University of Kyrgyzstan, Bishkek, Kyrgyzstan., Vuralli D; Department of Neurology and Algology, Neuropsychiatry Center, Neuroscience and Neurotechnology Center of Excellence (NÖROM), Gazi University, Ankara, Turkey., Bozhenko M; Department of Neurology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine., Azizova I; Neurological Clinic 'New Medical Technologies', Baku, Azerbaijan., Bitsadze N; Caucasus Medical Centre, Tbilisi, Georgia., Eralieva E; Osh City Clinical Hospital, Osh, Kyrgyzstan., Ashina M; Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark., Mitsikostas D; Department of Neurology Α, Aegintion Hospital, National and Kapidistrian University of Athens, Athens, Greece., Puledda F; Headache Group, Wolfson SPaRC, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jazyk: angličtina
Zdroj: Cephalalgia : an international journal of headache [Cephalalgia] 2023 Dec; Vol. 43 (12), pp. 3331024231218392.
DOI: 10.1177/03331024231218392
Abstrakt: Purpose: Treatments in medicine impact individuals beyond their intended effects, due to phenomena such as the placebo and nocebo effects. The placebo effect arises from the positive expectation of a treatment being beneficial, while the nocebo effect stems from the negative expectation of a treatment causing harm. Both in real-world practice and clinical trials, treatments can lead to outcomes unrelated to their intended mechanism of action, which we categorize as placebo and nocebo responses. These responses, combined with the inherent fluctuation in a condition's natural progression, regression to the mean, and random comorbidities, make up a significant part of the therapeutic experience. Particularly in pain management, placebo and nocebo effects play a substantial role. By addressing modifiable contextual factors such as patient expectations, lifestyle choices, and the therapeutic relationship, healthcare providers can enhance the effectiveness of migraine treatments, paving the way for a more comprehensive, individualized approach to patient care. We must also consider non-modifiable factors like personal experiences, beliefs, and information from social media and the internet.
Conclusion: This review offers a summary of our current understanding of the placebo and nocebo effects in migraine management.
Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje