| Autor: |
Biradar DO; Chemistry, Indian Institute of Chemical Technology, Hyderabad, India.; Maharashtra Mahavidyalaya, Nilanga, India., Mane YD; BSS Arts, Science & Commerce College, Makni, India., Yadav JS; Chemistry, Indian Institute of Chemical Technology, Hyderabad, India., Subba Reddy BV; Chemistry, Indian Institute of Chemical Technology, Hyderabad, India. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2023 Dec 02, pp. 1-11. Date of Electronic Publication: 2023 Dec 02. |
| DOI: |
10.1080/14786419.2023.2288694 |
| Abstrakt: |
A highly stereoselective total synthesis of polyrhacitide A, a polyketide natural product, has been accomplished by means of Prins cyclisation. The key precursor i.e. anti -1,3-diol for polyrhacitide A has been prepared from trans -2,6-disubstituted-3,4-dihydropyrans. In this approach, Prins cyclisation has successfully been utilised twice for the construction of 1,3-diol unit of polyrhacitide A. The key steps involved in this approach are Jacobsen hydrolytic kinetic resolution, Mitsunobu inversion, Prins cyclisation and Ring-closing metathesis (RCM). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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