Magnetic Chitosan Bionanocomposite Films as a Versatile Platform for Biomedical Hyperthermia.

Autor: Barra A; Department of Materials and Ceramic Engineering, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal.; Materials Science Institute of Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, Madrid, 28049, Spain., Wychowaniec JK; School of Chemistry, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland.; AO Research Institute Davos, Clavadelerstrasse 8, Davos, 7270, Switzerland., Winning D; School of Chemistry, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland., Cruz MM; Biosystems and Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, Lisboa, 1749-016, Portugal., Ferreira LP; Biosystems and Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, Lisboa, 1749-016, Portugal.; Physics Department, University of Coimbra, Coimbra, 3004-516, Portugal., Rodriguez BJ; School of Physics and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland., Oliveira H; Department of Biology and CESAM, University of Aveiro, Aveiro, 3810-193, Portugal., Ruiz-Hitzky E; Materials Science Institute of Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, Madrid, 28049, Spain., Nunes C; Department of Materials and Ceramic Engineering, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal., Brougham DF; School of Chemistry, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland., Ferreira P; Department of Materials and Ceramic Engineering, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Apr; Vol. 13 (11), pp. e2303861. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1002/adhm.202303861
Abstrakt: Responsive magnetic nanomaterials offer significant advantages for innovative therapies, for instance, in cancer treatments that exploit on-demand delivery on alternating magnetic field (AMF) stimulus. In this work, biocompatible magnetic bionanocomposite films are fabricated from chitosan by film casting with incorporation of magnetite nanoparticles (MNPs) produced by facile one pot synthesis. The influence of synthesis conditions and MNP concentration on the films' heating efficiency and heat dissipation are evaluated through spatio-temporal mapping of the surface temperature changes by video-thermography. The cast films have a thickness below 100 µm, and upon exposure to AMF (663 kHz, 12.8 kA m -1 ), induce exceptionally strong heating, reaching a maximum temperature increase of 82 °C within 270 s irradiation. Further, it is demonstrated that the films can serve as substrates that supply heat for multiple hyperthermia scenarios, including: i) non-contact automated heating of cell culture medium, ii) heating of gelatine-based hydrogels of different shapes, and iii) killing of cancerous melanoma cells. The films are versatile components for non-contact stimulus with translational potential in multiple biomedical applications.
(© 2023 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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