Reprogramming endothelial cells to empower cancer immunotherapy.

Autor: Cleveland AH; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Fan Y; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: fanyi@upenn.edu.
Jazyk: angličtina
Zdroj: Trends in molecular medicine [Trends Mol Med] 2024 Feb; Vol. 30 (2), pp. 126-135. Date of Electronic Publication: 2023 Nov 30.
DOI: 10.1016/j.molmed.2023.11.002
Abstrakt: Cancer immunity is subject to spatiotemporal regulation by leukocyte interaction with the tumor microenvironment. Growing evidence suggests an emerging role for the vasculature in tumor immune evasion and immunotherapy resistance. Beyond the conventional functions of the tumor vasculature, such as providing oxygen and nutrients to support tumor progression, we propose multiplex mechanisms for vascular regulation of tumor immunity: The immunosuppressive vascular niche locoregionally educates circulation-derived immune cells by angiocrines, aberrant endothelial metabolism induces T cell exclusion and inactivation, and topologically and biochemically abnormal vascularity forms a pathophysiological barrier that hampers lymphocyte infiltration. We postulate that genetic and metabolic reprogramming of endothelial cells may rewire the immunosuppressive vascular microenvironment to overcome immunotherapy resistance, serving as a next-generation vascular targeting strategy for cancer treatment.
Competing Interests: Declaration of interests The authors declare no competing financial interests.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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