Impact of Epicardial Adipose Tissue on Right Cardiac Function and Prognosis in Pulmonary Arterial Hypertension.
| Autor: | Chen Y; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Li J; Department of Medical Imaging, Huizhou Municipal Central Hospital, Huizhou, China., Li F; Department of Radiology and Imaging, Zhuzhou Central Hospital of Central South University, Zhuzhou, China., Chen Z; School of Information Science and Technology, Shanghaitech University, Shanghai City, China., Chen Z; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Luo J; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Qiu H; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Chen W; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Hu J; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Luo X; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Tan Y; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Rathinasabapathy A; Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN., Chen J; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China., Li J; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha City, China. Electronic address: lijiangcs@csu.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | Chest [Chest] 2024 May; Vol. 165 (5), pp. 1211-1223. Date of Electronic Publication: 2023 Nov 29. |
| DOI: | 10.1016/j.chest.2023.11.039 |
| Abstrakt: | Background: Although epicardial adipose tissue (EAT) is linked to effects on survival in left-sided heart failure, the association between EAT and right-sided heart failure caused by pulmonary arterial hypertension (PAH) remains unknown. Research Question: What are the potential impacts of EAT volume (EATV) on right ventricular function, biomarkers of myocardial injury, and long-term prognosis in patients with PAH? Study Design and Methods: A total of 135 age- and BMI-matched patients with PAH and 49 control participants were included in this study. EATV was quantified by using cardiac magnetic resonance and was related to clinical correlates, N-terminal pro-brain natriuretic peptide, and cardiac function. Levels of EATV associated with the risk of clinical worsening were evaluated on a continuous scale (restricted cubic splines) and by previously defined centile categories with Cox proportional hazards regression models and Kaplan-Meier survival estimates. Results: Compared with the control participants, patients with PAH had a lower EATV (ln [EATV], 3.2 ± 0.8 mL vs 3.5 ± 0.7 mL; P = .034). The association of EATV with right ventricular end-diastolic volume (P Interpretation: Patients with PAH had a decreased EATV compared with control participants. EATV exhibited a U-shaped association with right ventricular function and biomarkers of myocardial injury in patients with PAH. Low and high levels of EATV might reduce long-term event-free survival in patients with PAH. Clinical Trial Registration: Chinese Clinical Trial Registry; No. ChiCTR2100049804; www.chictr.org.cn. Competing Interests: Financial/Nonfinancial Disclosures None declared. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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