Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals.

Autor: Bonomi S; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Lu R; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Schindler SE; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Bui Q; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Lah JJ; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Wolk D; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Gleason CE; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Sperling R; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Roberson ED; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Levey AI; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Shaw L; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Van Hulle C; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Benzinger T; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Adams M; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Manzanares C; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Qiu D; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Hassenstab J; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Moulder KL; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Balls-Berry JE; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Johnson K; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Johnson SC; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Murchison CF; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Luo J; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Gremminger E; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Agboola F; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Grant EA; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Hornbeck R; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Massoumzadeh P; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Keefe S; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Dierker D; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Gray J; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Henson RL; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Streitz M; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Mechanic-Hamilton D; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Morris JC; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Xiong C; Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Jazyk: angličtina
Zdroj: Annals of neurology [Ann Neurol] 2024 Mar; Vol. 95 (3), pp. 495-506. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1002/ana.26838
Abstrakt: Objective: Biomarkers of Alzheimer disease vary between groups of self-identified Black and White individuals in some studies. This study examined whether the relationships between biomarkers or between biomarkers and cognitive measures varied by racialized groups.
Methods: Cerebrospinal fluid (CSF), amyloid positron emission tomography (PET), and magnetic resonance imaging measures were harmonized across four studies of memory and aging. Spearman correlations between biomarkers and between biomarkers and cognitive measures were calculated within each racialized group, then compared between groups by standard normal tests after Fisher's Z-transformations.
Results: The harmonized dataset included at least one biomarker measurement from 495 Black and 2,600 White participants. The mean age was similar between racialized groups. However, Black participants were less likely to have cognitive impairment (28% vs 36%) and had less abnormality of some CSF biomarkers including CSF Aβ42/40, total tau, p-tau181, and neurofilament light. CSF Aβ42/40 was negatively correlated with total tau and p-tau181 in both groups, but at a smaller magnitude in Black individuals. CSF Aβ42/40, total tau, and p-tau181 had weaker correlations with cognitive measures, especially episodic memory, in Black than White participants. Correlations of amyloid measures between CSF (Aβ42/40, Aβ42) and PET imaging were also weaker in Black than White participants. Importantly, no differences based on race were found in correlations between different imaging biomarkers, or in correlations between imaging biomarkers and cognitive measures.
Interpretation: Relationships between CSF biomarkers but not imaging biomarkers varied by racialized groups. Imaging biomarkers performed more consistently across racialized groups in associations with cognitive measures. ANN NEUROL 2024;95:495-506.
(© 2023 American Neurological Association.)
Databáze: MEDLINE
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