Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making.

Autor:	Nuiten SA; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland., de Gee JW; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands., Zantvoord JB; Department of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience, Amsterdam, Netherlands., Fahrenfort JJ; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.; Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Department of Experimental and Applied Psychology - Cognitive Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., van Gaal S; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Dec 01; Vol. 12. Date of Electronic Publication: 2023 Dec 01.
DOI:	10.7554/eLife.87022
Abstrakt:	Perceptual decisions about sensory input are influenced by fluctuations in ongoing neural activity, most prominently driven by attention and neuromodulator systems. It is currently unknown if neuromodulator activity and attention differentially modulate perceptual decision-making and/or whether neuromodulatory systems in fact control attentional processes. To investigate the effects of two distinct neuromodulatory systems and spatial attention on perceptual decisions, we pharmacologically elevated cholinergic (through donepezil) and catecholaminergic (through atomoxetine) levels in humans performing a visuo-spatial attention task, while we measured electroencephalography (EEG). Both attention and catecholaminergic enhancement improved decision-making at the behavioral and algorithmic level, as reflected in increased perceptual sensitivity and the modulation of the drift rate parameter derived from drift diffusion modeling. Univariate analyses of EEG data time-locked to the attentional cue, the target stimulus, and the motor response further revealed that attention and catecholaminergic enhancement both modulated pre-stimulus cortical excitability, cue- and stimulus-evoked sensory activity, as well as parietal evidence accumulation signals. Interestingly, we observed both similar, unique, and interactive effects of attention and catecholaminergic neuromodulation on these behavioral, algorithmic, and neural markers of the decision-making process. Thereby, this study reveals an intricate relationship between attentional and catecholaminergic systems and advances our understanding about how these systems jointly shape various stages of perceptual decision-making. Competing Interests: SN, Jd, JZ, JF, Sv No competing interests declared (© 2023, Nuiten et al.)
Databáze:	MEDLINE
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