Anthraquinones from Rhamnus alaternus L.: A Phytocosmetic Ingredient with Photoprotective and Antimelanogenesis Properties.

Autor: Bouhlel Chatti I; Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, 5000, Monastir, Tunisia.; Department of Biology and Geology, Higher Institute of Applied Science and Technology of Gabe s, University of Gabes, Gabes, Tunisia., Krichen Y; Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, 5000, Monastir, Tunisia., Horchani M; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019, Monastir, Tunisia., Maatouk M; Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, 5000, Monastir, Tunisia., Trabelsi A; Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, 5000, Monastir, Tunisia., Lassoued MA; Laboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy, University of Monastir, Rue Avicenne, Monastir, Tunisia., Ben Jannet H; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019, Monastir, Tunisia., Ghédira LC; Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, 5000, Monastir, Tunisia.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jan; Vol. 21 (1), pp. e202300876. Date of Electronic Publication: 2023 Dec 14.
DOI: 10.1002/cbdv.202300876
Abstrakt: The purpose of the present work was to develop a phytocosmetic sunscreen emulsion with antioxidant activity and an anti-melanogenic effect, containing an anthraquinone-enriched extract of Rhamnus alaternus (A.E.). Our findings demonstrated that A.E. decreased the levels of reactive oxygen species, DNA damage, and malondialdehyde induced by UVA in human keratinocytes and melanocytes. Furthermore, the calculated SPF value in vitro of the cream containing A.E. was 14.26±0.152. Later, it was shown that A.E. extract had an inhibitory effect on the amount of melanin. This extract could also reduce B16F10 intracellular tyrosinase activity. Besides, docking studies were carried out to provide a logical justification for the anti-tyrosinase potential. The findings showed that, A.E. may provide protection against UVA-induced oxidative stress and could be thought of as a viable treatment for hyperpigmentation disorders.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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