Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers.

Autor:	Ksila M; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia., Ghzaiel I; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.; Laboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia., Sassi K; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France., Zarrouk A; Laboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia.; Faculty of Medicine, University of Sousse, Laboratory of Biochemistry, Sousse, Tunisia., Leoni V; Department of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale Brianza ASST-Brianza, Desio Hospital, Desio, Italy., Poli G; Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Turin, Italy., Rezig L; University of Carthage, National Institute of Applied Sciences and Technology, LR11ES26, LIP-MB 'Laboratory of Protein Engineering and Bioactive Molecules', Tunis, Tunisia.; University of Carthage, High Institute of Food Industries, El Khadra City, Tunis, Tunisia., Pires V; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France., Meziane S; Institut Européen des Antioxydants (IEA), Neuves-Maisons, France., Atanasov AG; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Magdalenka, Poland., Hammami S; Laboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia.; University Hospital Fattouma Bourguiba, Monastir, Tunisia., Hammami M; Laboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia., Masmoudi-Kouki O; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia., Hamdi O; University Hospital Fattouma Bourguiba, Monastir, Tunisia.; Pôle Personnes Agées, CHU de Dijon, Centre de Champmaillot, Dijon Cedex, France., Jouanny P; Pôle Personnes Agées, CHU de Dijon, Centre de Champmaillot, Dijon Cedex, France., Samadi M; Laboratory of Chemistry and Physics Multi-Scale Approach to Complex Environments, Department of Chemistry, University Lorraine, Metz, France., Vejux A; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France., Ghrairi T; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia., Lizard G; Bio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France. gerard.lizard@u-bourgogne.fr.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1440, pp. 379-400.
DOI:	10.1007/978-3-031-43883-7_19
Abstrakt:	Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation, enzymatically, or by both processes. These molecules, which are provided in more or less important quantities depending on the type of diet, are also formed in the body and their presence is associated with a normal physiological activity. Their increase and decrease at the cellular level and in biological fluids can have significant consequences on health due or not to the interaction of some of these molecules with different types of receptors but also because oxysterols are involved in the regulation of RedOx balance, cytokinic and non-cytokinic inflammation, lipid metabolism, and induction of cell death. Currently, various pathologies such as age-related diseases, inflammatory and infectious diseases, and several cancers are associated with abnormal levels of oxysterols. Due to the important biological activities of oxysterols, their interaction with several receptors and their very likely implications in several diseases, this review focuses on these molecules and on oxysterol derivatives, which are often more efficient, in a therapeutic context. Currently, several oxysterol derivatives are developed and are attracting a lot of interest. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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