Breast cancer risk for the joint exposure to metals and metalloids in women: Results from the EPIC-Spain cohort.

Autor: Fernández-Martínez NF; Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain., Rodríguez-Barranco M; Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain. Electronic address: miguel.rodriguez.barranco.easp@juntadeandalucia.es., Huerta JM; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008 Murcia, Spain., Gil F; Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain., Olmedo P; Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain., Molina-Montes E; Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Nutrition and Food Science, University of Granada, 18011 Granada, Spain; Institute of Nutrition and Food Technology (INYTA) 'Jose Mataix', Biomedical Research Center, University of Granada, 18071 Granada, Spain., Guevara M; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Instituto de Salud Pública y Laboral de Navarra, 31003 Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain., Zamora-Ros R; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), 08908 Bellvitge, Spain; Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain., Jiménez-Zabala A; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain; BioGipuzkoa Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, 20014 San Sebastián, Spain., Colorado-Yohar SM; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008 Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Ardanaz E; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Instituto de Salud Pública y Laboral de Navarra, 31003 Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain., Bonet C; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), 08908 Bellvitge, Spain; Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain., Amiano P; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain; BioGipuzkoa Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, 20014 San Sebastián, Spain., Chirlaque MD; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008 Murcia, Spain., Pérez-Gómez B; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Epidemiology for Chronic Diseases, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain., Jiménez-Moleón JJ; Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Legal Medicine and Toxicology, University of Granada, 18016 Granada, Spain., Martín-Jiménez M; Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Complutense, 28007 Madrid, Spain; GEICAM, Spanish Breast Cancer Group, 28703 Madrid, Spain; Consorcio de Investigación Biomédica en Red de Oncología (CIBERONC), 28029 Madrid, Spain., de Santiago E; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, PTS Granada, 18016 Granada, Spain., Sánchez MJ; Instituto de Investigación Biosanitaria ibs, GRANADA, 18012 Granada, Spain; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain; Department of Legal Medicine and Toxicology, University of Granada, 18016 Granada, Spain.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Feb 20; Vol. 912, pp. 168816. Date of Electronic Publication: 2023 Nov 28.
DOI: 10.1016/j.scitotenv.2023.168816
Abstrakt: Environmental factors play a role in breast cancer development. While metals and metalloids (MMs) include some carcinogens, their association with breast cancer depends on the element studied. Most studies focus on individual MMs, but the combined effects of metal mixtures remain unclear. The aim of this study was to analyze the relationship between the joint exposure to MMs and the risk of developing female breast cancer. We conducted a case-control study within the multicenter prospective EPIC-Spain cohort. Study population comprised 292 incident cases and 286 controls. Plasma concentrations of 16 MMs were quantified at recruitment. Potential confounders were collected using a questionnaire and anthropometric measurements. Mixed-effects logistic regression models were built to explore the effect of individual MMs. Quantile-based g computation models were applied to identify the main mixture components and to estimate the joint effect of the metal mixture. The geometric means were highest for Cu (845.6 ng/ml) and Zn (604.8 ng/ml). Cases had significantly higher Cu concentrations (p = 0.010) and significantly lower Zn concentrations (p < 0.001). Cu (+0.42) and Mn (+0.13) showed the highest positive weights, whereas Zn (-0.61) and W (-0.16) showed the highest negative weights. The joint effect of the metal mixture was estimated at an OR = 4.51 (95%CI = 2.32-8.79), suggesting a dose-response relationship. No evidence of non-linearity or non-additivity was found. An unfavorable exposure profile, primarily characterized by high Cu and low Zn levels, could lead to a significant increase in the risk of developing female breast cancer. Further studies are warranted to confirm these findings.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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