Digital phenotyping: An equal opportunity approach to reducing disparities in Alzheimer's disease and related dementia research.

Autor: Britton GB; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) Panamá City Panama.; Universidad Santa María La Antigua, Vía Ricardo J. Alfaro Panamá City Panama., Huang LK; Taipei Medical University Shuang-Ho Hospital Taipei Taiwan., Villarreal AE; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) Panamá City Panama., Levey A; Emory University School of Medicine Atlanta Georgia USA., Philippakis A; Broad Institute at Massachusetts Institute of Technology and Harvard University Cambridge Massachusetts USA., Hu CJ; Taipei Medical University Shuang-Ho Hospital Taipei Taiwan., Yang CC; Taipei Medical University Shuang-Ho Hospital Taipei Taiwan., Mushi D; Kilimanjaro Christian Medical University College Moshi Tanzania., Oviedo DC; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) Panamá City Panama.; Universidad Santa María La Antigua, Vía Ricardo J. Alfaro Panamá City Panama., Rangel G; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) Panamá City Panama., Ho JS; Davos Alzheimer's Collaborative Wayne Pennsylvania USA.; Boston University School of Public Health Boston Massachusetts USA., Thompson L; Davos Alzheimer's Collaborative Wayne Pennsylvania USA.; Alpert Medical School of Brown University Providence Rhode Island USA., Khemakhem M; Davos Alzheimer's Collaborative Wayne Pennsylvania USA., Ross M; Davos Alzheimer's Collaborative Wayne Pennsylvania USA.; Boston University School of Public Health Boston Massachusetts USA., Carreira MB; Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) Panamá City Panama., Kim N; Davos Alzheimer's Collaborative Wayne Pennsylvania USA., Joung P; Davos Alzheimer's Collaborative Wayne Pennsylvania USA., Albastaki O; Davos Alzheimer's Collaborative Wayne Pennsylvania USA., Kuo PC; National Tsing Hua University, East District HsinChu Taiwan., Low S; Davos Alzheimer's Collaborative Wayne Pennsylvania USA.; Boston University School of Public Health Boston Massachusetts USA.; Boston University Chobanian and Avedisian School of Medicine Boston Massachusetts USA.; Boston University Alzheimer's Disease Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Paddick SM; Gateshead Health NHS Foundation Trust Gateshead UK., Kuan YC; Taipei Medical University Shuang-Ho Hospital Taipei Taiwan., Au R; Davos Alzheimer's Collaborative Wayne Pennsylvania USA.; Boston University School of Public Health Boston Massachusetts USA.; Boston University Chobanian and Avedisian School of Medicine Boston Massachusetts USA.; Boston University Alzheimer's Disease Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; The Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine, Boston University School of Public Health Framingham Massachusetts USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2023 Nov 29; Vol. 15 (4), pp. e12495. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
DOI: 10.1002/dad2.12495
Abstrakt: A rapidly aging world population is fueling a concomitant increase in Alzheimer's disease (AD) and related dementias (ADRD). Scientific inquiry, however, has largely focused on White populations in Australia, the European Union, and North America. As such, there is an incomplete understanding of AD in other populations. In this perspective, we describe research efforts and challenges of cohort studies from three regions of the world: Central America, East Africa, and East Asia. These cohorts are engaging with the Davos Alzheimer's Collaborative (DAC), a global partnership that brings together cohorts from around the world to advance understanding of AD. Each cohort is poised to leverage the widespread use of mobile devices to integrate digital phenotyping into current methodologies and mitigate the lack of representativeness in AD research of racial and ethnic minorities across the globe. In addition to methods that these three cohorts are already using, DAC has developed a digital phenotyping protocol that can collect ADRD-related data remotely via smartphone and/or in clinic via a tablet to generate a common data elements digital dataset that can be harmonized with additional clinical and molecular data being collected at each cohort site and when combined across cohorts and made accessible can provide a global data resource that is more racially/ethnically represented of the world population.
Competing Interests: Dr. Au serves as a scientific advisor and/or consultant to Signant Health, Biogen, and the Davos Alzheimer's Collaborative. No other authors have any conflicts of interest to declare. Author disclosures are available in the supporting information.
(© 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: