Metastatic Salivary Duct Carcinoma with ERBB2 Amplification and Sequential Response to Ado-Trastuzumab Emtansine and Neratinib: A Case Report.

Autor: Asper N; University of Zurich, Zurich, Switzerland., Roth KS; University of Zurich, Zurich, Switzerland., Hany TF; MRI Stadelhofen, Zurich, Switzerland., Salzberg SP; Swiss Ablation, Zurich, Switzerland., Tinguely M; Pathologie Institut Enge, Zurich, Switzerland., Kadvany Y; Mobile Health, Zurich, Switzerland., Trojan A; BrustZentrum Zürichsee, Horgen, Switzerland.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2023 Nov 29; Vol. 16 (1), pp. 1500-1507. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
DOI: 10.1159/000535097
Abstrakt: Introduction: Salivary duct carcinoma (SDC) is an aggressive and rare subtype of salivary gland carcinoma. Surgical excision and radiotherapy are standard of care for early cancer. Chemotherapies with taxanes and platinum show overall response rates between 39% and 50%. SDCs are often associated with an overexpression of the androgen receptor (AR) and HER2/neu which have recently become druggable targets.
Case Presentation: Here, we report on an 84-year-old male patient with metastatic SDC of the right parotid gland. In 2017, he underwent a right total parotidectomy, a right neck dissection, and an infratemporal fossa clearance followed by 6 weeks of radiotherapy. In 2018, due to metastatic spread in the lungs, bones, and pararenal gland, a pathological workup of the tumor tissue was performed and revealed both AR and HER2 overexpression, respectively. Consequently, he underwent androgen deprivation therapy and, due to asymptomatic progression, sequentially human epidermal growth factor receptor 2 (HER-2)-targeted therapy with ado-trastuzumab emtansine and neratinib, which led to stable disease during the course of about 18 months. The electronically captured patient-reported outcome had demonstrated a good tolerance of all three therapeutic lines.
Conclusion: In conclusion, since effective standard therapeutic treatment options for SDC may often not be tolerable in older patients, the implementation of personalized and adaptive treatments, especially in patients with rare tumor types, might offer valuable treatment options.
Competing Interests: A.T. is an initiator and stock owner of mobile Health AG, a startup company that operates the Medidux Smartphone App. He serves as a chief medical officer for the startup company. Y.K. is the commercial project manager and customer success manager of mobile Health AG.
(© 2023 The Author(s). Published by S. Karger AG, Basel.)
Databáze: MEDLINE
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