Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography.

Autor: Kwok HY; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China., Kwok HY; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China., Ng TN; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China., Leung TW; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China.; Research Centre for Sharp Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China.; Centre for Eye and Vision Research Limited, Hong Kong, SAR, China., Kang BS; Centre for Eye and Vision Research Limited, Hong Kong, SAR, China., Kee CS; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China.; Research Centre for Sharp Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China.; Centre for Eye and Vision Research Limited, Hong Kong, SAR, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 30; Vol. 18 (11), pp. e0289135. Date of Electronic Publication: 2023 Nov 30 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0289135
Abstrakt: Objective: To characterize and compare the ciliary muscle thickness (CMT) between low and high myopes using swept-source anterior segment optical coherence tomography (AS-OCT).
Methods: Forty visually healthy young Chinese adults aged 18-25 years were divided into two groups based on refractive errors: low myopia (n = 20, spherical-equivalent refractive error (SER) between -0.50 D to -3.00 D) and high myopia (n = 20, SER ≤ -6.00 D). Cycloplegic refractions were performed before axial length (AL) and CMT were measured using a partial coherence laser interferometer and an AS-OCT respectively. CMT was measured perpendicularly to the sclera-ciliary muscle interface at 1 mm (CMT_1), 2 mm (CMT_2), and 3 mm (CMT_3) posterior to the scleral spur, and at the location with maximal thickness (CMT_MAX).
Results: High myopes demonstrated thicker CMT at 2 mm (CMT_2, p = 0.035) and 3 mm (CMT_3, p = 0.003) posterior to the scleral spur, but thinner maximal CMT (CMT_MAX, p = 0.005) than low myopes. The apical CMT_1 and CMT_MAX were also thinner in high myopes than in low myopes (both p< 0.001). CMT_MAX, apical CMT_1, and apical CMT_MAX correlated directly with SER and inversely with AL; in contrast, CMT_2 and CMT_3 showed inverse correlations with SER but direct correlations with AL.
Conclusion: Our findings revealed significant differences in CMT between low and high myopes, with high myopes showing thicker CMT at 2 mm and 3 mm posterior to the scleral spur, but thinner maximal CMT. These results provide new evidence of the potential structural differences in ciliary muscles during myopia development and progression.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Kwok et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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