Mortality Among Children Aged <5 Years Living with HIV Who Are Receiving Antiretroviral Treatment - U.S. President's Emergency Plan for AIDS Relief, 28 Supported Countries and Regions, October 2020-September 2022.

Autor: Agathis NT, Faturiyele I, Agaba P, Fisher KA, Hackett S, Agyemang E, Mehta N, Kindra G, Morof DF, Mutisya I, Nyabiage L, Battey KA, Olotu E, Maphosa T, Motswere-Chirwa C, Ketlogetswe AT, Mafa-Setswalo J, Mazibuko S, de Deus MIT, Nhaguiombe HG, Machage EM, Mugisa B, Ogundehin DT, Mbelwa C, Birabwa E, Etima M, Adamu Y, Lawal I, Maswai J, Njeru D, Mwambona J, Nguhuni B, Mrina R, Hrapcak S, Siberry GK, Godfrey C, Wolf HT
Jazyk: angličtina
Zdroj: MMWR. Morbidity and mortality weekly report [MMWR Morb Mortal Wkly Rep] 2023 Dec 01; Vol. 72 (48), pp. 1293-1299. Date of Electronic Publication: 2023 Dec 01.
DOI: 10.15585/mmwr.mm7248a1
Abstrakt: Globally, children aged <5 years, including those living with HIV who are not receiving antiretroviral treatment (ART), experience disproportionately high mortality. Global mortality among children living with HIV aged <5 years receiving ART is not well described. This report compares mortality and related clinical measures among infants aged <1 year and children aged 1-4 years living with HIV with those among older persons aged 5-14, 15-49, and ≥50 years living with HIV receiving ART services at all clinical sites supported by the U.S. President's Emergency Plan for AIDS Relief. During October 2020-September 2022, an average of 11,980 infants aged <1 year and 105,510 children aged 1-4 years were receiving ART each quarter; among these infants and children receiving ART, 586 (4.9%) and 2,684 (2.5%), respectively, were reported to have died annually. These proportions of infants and children who died ranged from four to nine times higher in infants aged <1 year, and two to five times higher in children aged 1-4 years, than the proportions of older persons aged ≥5 years receiving ART. Compared with persons aged ≥5 years living with HIV, the proportions of children aged <5 years living with HIV who experienced interruptions in treatment were also higher, and the proportions who had a documented HIV viral load result or a suppressed viral load were lower. Prioritizing and optimizing HIV and general health services for children aged <5 years living with HIV receiving ART, including those recommended in the WHO STOP AIDS Package, might help address these disproportionately poorer outcomes.
Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.
Databáze: MEDLINE
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