The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for school-age follow-up.

Autor:	Piper JD; Blizard Institute, Queen Mary University of London, London, England, UK.; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mazhanga C; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mwapaura M; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mapako G; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mapurisa I; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mashedze T; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Munyama E; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Kuona M; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mashiri T; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Sibanda K; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Matemavi D; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Tichagwa M; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Nyoni S; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Saidi A; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mangwende M; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Chidhanguro D; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mpofu E; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Tome J; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Mutasa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Chasekwa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Smuk M; Blizard Institute, Queen Mary University of London, London, England, UK., Smith LE; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe.; Cornell University, Ithaca, New York, USA., Njovo H; Ministry of Health and Child Care, Harare, Zimbabwe., Nyachowe C; Ministry of Health and Child Care, Harare, Zimbabwe., Muchekeza M; Ministry of Health and Child Care, Harare, Zimbabwe., Mutasa K; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Sauramba V; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Langhaug LF; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Tavengwa NV; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Gladstone MJ; Institute of Translational Medicine, University of Liverpool, Liverpool, England, UK., Wells JC; Population Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Allen E; London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Humphrey JH; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Ntozini R; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe., Prendergast AJ; Blizard Institute, Queen Mary University of London, London, England, UK.; Zvitambo Institute for Maternal and Child Health Research, Harare, Harare Province, Zimbabwe.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	Wellcome open research [Wellcome Open Res] 2023 Jul 14; Vol. 8, pp. 306. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).
DOI:	10.12688/wellcomeopenres.19463.1
Abstrakt:	Background : There is a need for follow-up of early-life stunting intervention trials into childhood to determine their long-term impact. A holistic school-age assessment of health, growth, physical and cognitive function will help to comprehensively characterise the sustained effects of early-life interventions. Methods: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe assessed the effects of improved infant and young child feeding (IYCF) and/or improved water, sanitation and hygiene (WASH) on stunting and anaemia at 18 months. Among children enrolled to SHINE, 1,275 have been followed up at 7-8 years of age (1,000 children who have not been exposed to HIV, 268 exposed to HIV antenatally who remain HIV negative and 7 HIV positive children). Children were assessed using the School-Age Health, Activity, Resilience, Anthropometry and Neurocognitive (SAHARAN) toolbox, to measure their growth, body composition, cognitive and physical function. In parallel, a caregiver questionnaire assessed household demographics, socioeconomic status, adversity, nurturing, caregiver support, food and water insecurity. A monthly morbidity questionnaire is currently being administered by community health workers to evaluate school-age rates of infection and healthcare-seeking. The impact of the SHINE IYCF and WASH interventions, the early-life 'exposome', maternal HIV, and contemporary exposures on each school-age outcome will be assessed. We will also undertake an exploratory factor analysis to generate new, simpler metrics for assessment of cognition (COG-SAHARAN), growth (GROW-SAHARAN) and combined growth, cognitive and physical function (SUB-SAHARAN). The SUB-SAHARAN toolbox will be used to conduct annual assessments within the SHINE cohort from ages 8-12 years. Ethics and dissemination: Approval was obtained from Medical Research Council of Zimbabwe (08/02/21) and registered with Pan-African Clinical Trials Registry (PACTR202201828512110, 24/01/22). Primary caregivers provided written informed consent and children written assent. Findings will be disseminated through community sensitisation, peer-reviewed journals and stakeholders including the Zimbabwean Ministry of Health and Child Care. Competing Interests: No competing interests were disclosed. (Copyright: © 2023 Piper JD et al.)
Databáze:	MEDLINE
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