DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.

Autor: Carrión O; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China. O.Carrion-Fonseca@uea.ac.uk.; School of Biological Sciences, University of East Anglia, Norwich, UK. O.Carrion-Fonseca@uea.ac.uk., Li CY; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China. Lcy@ouc.edu.cn., Peng M; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China.; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China., Wang J; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China., Pohnert G; Institute of Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Jena, Germany., Azizah M; Institute of Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Jena, Germany., Zhu XY; School of Biological Sciences, University of East Anglia, Norwich, UK., Curson ARJ; School of Biological Sciences, University of East Anglia, Norwich, UK., Wang Q; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China., Walsham KS; School of Biological Sciences, University of East Anglia, Norwich, UK., Zhang XH; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China., Monaco S; School of Pharmacy, University of East Anglia, Norwich, UK., Harvey JM; Department of Chemistry, King's College London, London, UK., Chen XL; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China., Gao C; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China., Wang N; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China., Wang XJ; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China., Wang P; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China., Giovanonni SJ; Department of Microbiology, Oregon State University, Corvallis, OR, USA., Lee CP; Department of Microbiology, Oregon State University, Corvallis, OR, USA., Suffridge CP; Department of Microbiology, Oregon State University, Corvallis, OR, USA., Zhang Y; State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen, China., Luo Z; State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen, China., Wang D; State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen, China., Todd JD; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China. jonathan.todd@uea.ac.uk.; School of Biological Sciences, University of East Anglia, Norwich, UK. jonathan.todd@uea.ac.uk., Zhang YZ; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, China. zhangyz@sdu.edu.cn.; State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, China. zhangyz@sdu.edu.cn.; Frontiers Science Center for Deep Ocean Multispheres and Earth System, Qingdao, China. zhangyz@sdu.edu.cn.; Joint Research Center for Marine Microbial Science and Technology, Shandong University and Ocean University of China, Qingdao, China. zhangyz@sdu.edu.cn.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2023 Dec; Vol. 8 (12), pp. 2326-2337. Date of Electronic Publication: 2023 Nov 29.
DOI: 10.1038/s41564-023-01526-4
Abstrakt: Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase 'Ddd' or 'Alma' enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.
(© 2023. The Author(s).)
Databáze: MEDLINE
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