Two new compounds from endemic Centaurea paphlagonica (Bornm.) Wagenitz and their cytotoxic activities.

Autor: Tüfekçi AR; Department of Chemistry, Faculty of Natural Sciences, Çankırı Karatekin University, Çankırı, Turkey., Demirtaş İ; Department of Biochemistry, Faculty of Arts and Sciences, Iğdır University, Iğdır, Turkey.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ondokuz Mayıs University, Samsun, Turkey., Akşit H; Department of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkey., Arslan Ş; Department of Biology, Faculty of Arts and Sciences, Pamukkale University, Denizli, Turkey., Kocabıyık K; Department of Biology, Faculty of Arts and Sciences, Pamukkale University, Denizli, Turkey., Zeybek S; Department of Biology, Faculty of Arts and Sciences, Pamukkale University, Denizli, Turkey., Ozen T; Department of Chemistry, Faculty of Science, Ondokuz Mayıs University, Samsun, Turkey., Köksal E; Department of Chemistry, Faculty of Science and Arts, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Jazyk: angličtina
Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2024 Jan; Vol. 103 (1), pp. e14409. Date of Electronic Publication: 2023 Nov 29.
DOI: 10.1111/cbdd.14409
Abstrakt: Centaurea paphlagonica (Bornm.) Wagenitz is an endemic plant in Turkey. Pyrocatechol, vanillic acid, 3,4-dihydroxy benzoic acid, 5-O-caffeoylshikimic acid, tamarixetin, chlorogenic acid methyl ester, quercetin, 1,3-dicaffeoylquinic acid, tamarixetin-7-O-β-D-glucopyranoside, quercimetrin, daucosterin, paphlagonicanin B, tamarixetin-7-O-β-rutinoside, rutin, chlorogenic acid, isoorientin, orientin, 3-O-feruloylquinic acid, quercetagetin-3-methyl ether 6-O-β-glucopyranoside, diosmetin 6-C-β-glucopyranoside, quercetagetin 4'-methyl ether 7-O-β-glucopyranoside, paphlagonicanin A, nepetin, cirsiliol, desacylcynaropicrin, and 8α-O-(2',3'-dihydroxyisobutyryl) desacylcynaropicrin were isolated from both flower and aerial parts of C. paphlagonica. These compounds were identified using 1D and 2D NMR methods and ESI-MS. The MTT assay assessed the antiproliferative activities of all isolated (known and new compounds) compounds on Caco-2, LNCaP, A549, HeLa, and HEK-293 cell lines. The 8α-O-(2',3'-dihydroxyisobutyryl) desacylcynaropicrin demonstrated the highest activity against CaCo-2 and HeLa cancer cell lines.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: