SARS-CoV-2 infection among healthcare workers: the role of occupational and household exposures during the first three pandemic waves in Quebec, Canada.

Autor:	Carazo S; Biological and Occupational Risks Unit, Institut national de santé publique du Québec, Quebec City, QC, Canada.; Social and Preventive Medicine Department, Faculty of Medicine, Laval University, Quebec City, QC, Canada., Denis G; School of Population and Global Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Public Health Department, CIUSSS Centre Sud de Montréal, Montreal, QC, Canada.; General Directorate of Public Health, Quebec Ministry of Health and Social Services, Quebec City, QC, Canada., Padet L; Biological and Occupational Risks Unit, Institut national de santé publique du Québec, Quebec City, QC, Canada., Deshaies P; Public Health Department, CISSS de Chaudière-Appalaches, Levis, QC, Canada., Villeneuve J; Biological and Occupational Risks Unit, Institut national de santé publique du Québec, Quebec City, QC, Canada., Paquet-Bolduc B; Infection Prevention and Control Unit, Institut Universitaire en cardiologie et pneumologie de Québec, Quebec City, QC, Canada., Laliberté D; Public Health Department, CIUSSS de la Capitale-Nationale, Quebec City, QC, Canada., Talbot D; Social and Preventive Medicine Department, Faculty of Medicine, Laval University, Quebec City, QC, Canada.; CHU de Québec-Laval University Research Center, Quebec City, QC, Canada., De Serres G; Biological and Occupational Risks Unit, Institut national de santé publique du Québec, Quebec City, QC, Canada.; Social and Preventive Medicine Department, Faculty of Medicine, Laval University, Quebec City, QC, Canada.; CHU de Québec-Laval University Research Center, Quebec City, QC, Canada.
Jazyk:	angličtina
Zdroj:	Antimicrobial stewardship & healthcare epidemiology : ASHE [Antimicrob Steward Healthc Epidemiol] 2023 Oct 20; Vol. 3 (1), pp. e180. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).
DOI:	10.1017/ash.2023.442
Abstrakt:	Objective: We described the evolution of SARS-CoV-2 source of infection in a cohort of healthcare workers (HCWs) of Quebec, Canada, during the first three pandemic waves. We also estimated their household secondary attack rate (SAR) and its risk factors. Design: Cross-sectional surveys. Participants: HCWs with a SARS-CoV-2 infection confirmed by polymerasa chain reaction and diagnosed between March 2020 and May 2021. Methods: We collected demographic, clinical, vaccination, and employment information, self-reported perceived source of infection, and transmission to household members during the first three pandemic waves. SAR was calculated for households with ≥2 members where the HCW was the index case. A Poisson regression model estimated the association between risk factors and SAR. Results: Among the 11,670 HCWs completing the survey, 91%, perceived their workplace as the source of infection during the first wave (March-July 2020), 71% during the second wave (July 2020-March 2021), and 40% during the third wave (March-May 2021). Conversely, HCWs reported an increasing proportion of household-acquired infections with each wave from 4% to 14% and 33%, respectively. The overall household SAR of 7,990 HCWs living with ≥1 person was 30% (95%CI: 29-30). SAR increased with the presence of symptoms, older age, and during Alpha-variant predominant period. Conclusions: HCWs and their household members were largely affected during the first pandemic waves of COVID-19, but the relative importance of occupational exposure changed overtime. Pandemic preparedness in healthcare settings is essential to protect HCWs from emerging biological hazard exposures. Competing Interests: SC and GDS report funding from the Ministère de la santé et des services sociaux du Québec to conduct this work, paid to their institution. GD reports participation as a medical advisor on the provincial public health scientific committee on COVID-19 for Quebec Ministry of Health. DT is supported by a research career award from the Fonds de recherche du Québec-Santé, paid to his institution. All other authors report no potential conflicts. (© Cambridge University Press 2023.)
Databáze:	MEDLINE
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