Differential metabolic alterations in IDH1 mutant vs. wildtype glioma cells promote epileptogenesis through distinctive mechanisms.
| Autor: | McAfee D; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Moyer M; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Queen J; The College of Arts and Sciences, Cornell University, Ithaca, NY, United States., Mortazavi A; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States., Boddeti U; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Bachani M; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Zaghloul K; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, United States., Ksendzovsky A; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 Nov 09; Vol. 17, pp. 1288918. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023). |
| DOI: | 10.3389/fncel.2023.1288918 |
| Abstrakt: | Glioma-related epilepsy (GRE) is a hallmark clinical presentation of gliomas with significant impacts on patient quality of life. The current standard of care for seizure management is comprised of anti-seizure medications (ASMs) and surgical resection. Seizures in glioma patients are often drug-resistant and can often recur after surgery despite total tumor resection. Therefore, current research is focused on the pro-epileptic pathological changes occurring in tumor cells and the peritumoral environment. One important contribution to seizures in GRE patients is metabolic reprogramming in tumor and surrounding cells. This is most evident by the significantly heightened seizure rate in patients with isocitrate dehydrogenase mutated (IDH mut ) tumors compared to patients with IDH wildtype (IDH wt ) gliomas. To gain further insight into glioma metabolism in epileptogenesis, this review compares the metabolic changes inherent to IDH mut vs. IDH wt tumors and describes the pro-epileptic effects these changes have on both the tumor cells and the peritumoral environment. Understanding alterations in glioma metabolism can help to uncover novel therapeutic interventions for seizure management in GRE patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 McAfee, Moyer, Queen, Mortazavi, Boddeti, Bachani, Zaghloul and Ksendzovsky.) |
| Databáze: | MEDLINE |
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