Detection of antimicrobial-resistant Enterobacterales in insectivorous bats from Chile.

Autor:	Rojas-Sereno ZE; Centro de Investigación para la Sustentabilidad y Doctorado en Medicina de la Conservación /Facultad Ciencias de la Vida, Universidad Andrés Bello, República 440, Santiago 8320000, Chile., Streicker DG; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G12 8QQ, UK.; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK., Suarez-Yana T; Centro de Investigación para la Sustentabilidad y Doctorado en Medicina de la Conservación /Facultad Ciencias de la Vida, Universidad Andrés Bello, República 440, Santiago 8320000, Chile., Lineros M; Sección Rabia, Departamento Laboratorio Biomédico, Instituto de Salud Pública de Chile, Santiago 8320000, Chile., Yung V; Sección Rabia, Departamento Laboratorio Biomédico, Instituto de Salud Pública de Chile, Santiago 8320000, Chile., Godreuil S; Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier 34295, France.; Laboratoire Mixte International, DRISA, IRD, Montpellier 34394, France.; MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier 34394, France., Benavides JA; Centro de Investigación para la Sustentabilidad y Doctorado en Medicina de la Conservación /Facultad Ciencias de la Vida, Universidad Andrés Bello, República 440, Santiago 8320000, Chile.; MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier 34394, France.
Jazyk:	angličtina
Zdroj:	Royal Society open science [R Soc Open Sci] 2023 Nov 08; Vol. 10 (11), pp. 231177. Date of Electronic Publication: 2023 Nov 08 (Print Publication: 2023).
DOI:	10.1098/rsos.231177
Abstrakt:	Enterobacterales of clinical importance for humans and domestic animals are now commonly detected among wildlife worldwide. However, few studies have investigated their prevalence among bats, particularly in bat species living near humans. In this study, we assessed the occurrence of Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemase-resistant (CR) Enterobacterales in rectal swabs of bats submitted to the Chilean national rabies surveillance program from 2021 to 2022. From the 307 swabs screened, 47 (15%) harboured cefotaxime-resistant Enterobacterales. Bats carrying these bacteria originated from 9 out of the 14 Chilean regions. Most positive samples were obtained from Tadarida brasiliensis ( n = 42), but also Lasiurus varius , L. cinereus and Histiotus macrotus . No Enterobacterales were resistant to imipenem. All ESBL-Enterobacterales were confirmed as Rahnella aquatilis by MALDI-TOF. No other ESBL or CR Enterobacterales were detected. To our knowledge, this is the first screening of antibiotic-resistant bacteria in wild bats of Chile, showing the bat faecal carriage of R. aquatilis naturally resistant to cephalosporins, but also including acquired resistance to important antibiotics for public health such as amoxicillin with clavulanic acid. Our results suggest unknown selective pressures on R. aquatilis , but low or no carriage of ESBL or CR Escherichia coli and Klebsiella spp. Future studies should assess the zoonotic and environmental implications of R. aquatilis , which are likely present in the guano left by bats roosting in human infrastructures. Competing Interests: We have no competing interests. (© 2023 The Authors.)
Databáze:	MEDLINE
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