Comparative study of efficacy and safety of cetirizine and bilastine in patients of chronic spontaneous urticaria: Open-label, randomized, parallel-group study.

Autor: Sinha VV; Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India., Kalikar MV; Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India., Mukhi JI; Department of Dermatology, Government Medical College, Nagpur, Maharashtra, India., Giradkar AB; Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India., Sontakke S; Department of Pharmacology, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra, India.
Jazyk: angličtina
Zdroj: Perspectives in clinical research [Perspect Clin Res] 2023 Oct-Dec; Vol. 14 (4), pp. 180-186. Date of Electronic Publication: 2023 Aug 08.
DOI: 10.4103/picr.picr_28_23
Abstrakt: Purpose: Bilastine is a novel second-generation antihistaminic. Very few studies in Indian population have compared the safety and efficacy of bilastine with other second-generation antihistaminic like cetirizine. Hence, the present study was planned.
Materials and Methods: This was a randomized, open-label comparative parallel group study conducted on 70 patients of chronic spontaneous urticaria (CSU). Patients either received cetirizine 10 mg or bilastine 20 mg once daily for 6 weeks. The primary endpoint was to find out the difference in the mean total symptom score (MTSS) at baseline and 6 weeks. The secondary endpoint was to find out changes in the scale of the number of wheals, change in pruritus scale, scale for size of wheal, change for interference of wheals with sleep, change in visual analog scale (VAS) for sedation, change in scale for intensity of erythema, and change in Scale for Extent of Skin Area Involvement (SESI).
Results: Bilastine and cetirizine offer a significant reduction in MTSS, mean number of wheals, and mean pruritus scale at baseline to 1, 3, and 6 weeks. The mean difference in MTSS was significantly more in bilastine. Cetirizine showed a significant increase in VAS score for sedation as compared to bilastine. Both the drugs were well tolerated and safe. Adverse events like headache, gastric irritation, dryness of mouth, and sedation were more reported in cetirizine group.
Conclusion: Bilastine was more efficacious than cetirizine in patients of CSU and the efficacy was seen earlier at 1 week, which was not seen in the cetirizine group.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Perspectives in Clinical Research.)
Databáze: MEDLINE
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