Exploring marine toxins: comparative analysis of chemical reactivity properties and potential for drug discovery.
| Autor: | Flores-Holguín N; Centro de Investigación en Materiales Avanzados SC, Chihuahua, Mexico., Salas-Leiva JS; Centro de Investigación en Materiales Avanzados SC, Chihuahua, Mexico., Núñez-Vázquez EJ; Centro de Investigaciones Biológicas del Noroeste, La Paz, Baja California Sur, Mexico., Tovar-Ramírez D; Centro de Investigaciones Biológicas del Noroeste, La Paz, Baja California Sur, Mexico., Glossman-Mitnik D; Centro de Investigación en Materiales Avanzados SC, Chihuahua, Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in chemistry [Front Chem] 2023 Nov 01; Vol. 11, pp. 1286804. Date of Electronic Publication: 2023 Nov 01 (Print Publication: 2023). |
| DOI: | 10.3389/fchem.2023.1286804 |
| Abstrakt: | Marine toxins, produced by various marine microorganisms, pose significant risks to both marine ecosystems and human health. Understanding their diverse structures and properties is crucial for effective mitigation and exploration of their potential as therapeutic agents. This study presents a comparative analysis of two hydrophilic and two lipophilic marine toxins, examining their reactivity properties and bioavailability scores. By investigating similarities among these structurally diverse toxins, valuable insights into their potential as precursors for novel drug development can be gained. The exploration of lipophilic and hydrophilic properties in drug design is essential due to their distinct implications on drug distribution, elimination, and target interaction. By elucidating shared molecular properties among toxins, this research aims to identify patterns and trends that may guide future drug discovery efforts and contribute to the field of molecular toxinology. The findings from this study have the potential to expand knowledge on toxins, facilitate a deeper understanding of their bioactivities, and unlock new therapeutic possibilities to address unmet biomedical needs. The results showcased similarities among the studied systems, while also highlighting the exceptional attributes of Domoic Acid (DA) in terms of its interaction capabilities and stability. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer SK declared a past co-authorship with the author NF-H, DG-M to the handling editor. (Copyright © 2023 Flores-Holguín, Salas-Leiva, Núñez-Vázquez, Tovar-Ramírez and Glossman-Mitnik.) |
| Databáze: | MEDLINE |
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