Phytochemistry and Cytotoxic Activity of Aquilaria crassna Pericarp on MDA-MB-468 Cell Lines.

Autor:	Nguyen TTT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam., Pham TNM; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam., Nguyen CTN; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam., Truong TN; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam., Bishop C; Center of Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, U.K., Doan NQH; Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Ward 13, Binh Thanh District, Ho Chi Minh City 70000, Vietnam., Le THV; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Oct 31; Vol. 8 (45), pp. 42356-42366. Date of Electronic Publication: 2023 Oct 31 (Print Publication: 2023).
DOI:	10.1021/acsomega.3c04656
Abstrakt:	The extracts of Aquilaria crassna pericarp were investigated on the MDA-MB-468, a breast cancer cell line, at desired concentration (1-50 μg/mL). The results showed that the dichloromethane (DCM) extract exhibited the strongest toxicity and was carried out subsequently. A total of nine compounds were isolated from the DCM extract using column chromatography and recrystallization, of which their structures were determined. Intriguingly, in addition to the previously reported compounds, neocucurbitacin A, a cucurbitacin triterpenoid aglycone with a lactone in ring A, was reported for the first time in the Aquilaria genus. Among the isolated compounds, cucurbitacin E highly inhibited MDA-MB-468 cell growth in a dose-dependent manner. Owing to binding abilities with the SH2 domain in the molecular docking study, cucurbitacin E, neocucurbitan A, neocucurbitan B, and cucurbitacin E 2- O -β-d-glucopyranoside act as STAT3 inhibitors and are suitable for further research. This study suggests that Aquilaria crassna fruits could serve as a promising source of natural compounds with potential anticancer effects, particularly against breast cancer. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu