Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease.

Autor: Ahmadi ZA; Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Dizaji MM; Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Sadeghpour A; Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Khesali H; Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Firouzi A; Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2023 Jul 28; Vol. 28, pp. 62. Date of Electronic Publication: 2023 Jul 28 (Print Publication: 2023).
DOI: 10.4103/jrms.jrms_4_21
Abstrakt: Background: The shape of the left ventricle (LV) is an important index to explore cardiac pathophysiology. A comparison was provided to estimate circumferential, longitudinal, and radial wall stress in LV based on the thick-walled ellipsoidal models of Mirsky and Ghista-Sandler for discriminating significant coronary artery disease (CAD) patients from no CAD patients.
Materials and Methods: According to the angiography findings, 82 patients with CAD were divided into two groups: 25 patients without significant CAD and 57 patients with significant CAD of single vessel and multivessel. An ellipsoidal LV geometry was used to calculate end-systolic passive stress as the mechanical behavior of LV. Echocardiographic views-based measurements of LV diameters used to estimate the end-systolic wall stress.
Results: Circumferential wall stress between the control group and significant CAD groups was significantly elevated for the Ghista model ( P = 0.008); also, radial and longitudinal stress of the multi-vessel CAD group was significantly higher than the control group ( P = 0.01 and P = 0.005, respectively). All stress parameters of the multi-vessel CAD group were statistically significant compared to the control group for the Mirsky model. Receiver operating characteristics curve analysis was shown the circumferential stress of multi-vessel CAD with an area under the curve (AUC) of 0.736 for the Ghista model and an AUC of 0.742 for the Mirsky model.
Conclusion: These results indicated that Ghista and Mirsky model estimates of circumferential passive stress were the potential biomechanical markers to predict patients with multi-vessel CAD. It could be a noninvasive and helpful tool to quantify the contractility of LV.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Journal of Research in Medical Sciences.)
Databáze: MEDLINE
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