Fat intake impairs the recovery of endothelial function following mental stress in young healthy adults.

Autor:	Baynham R; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom., Weaver SRC; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.; Centre for Human Brain Health, University of Birmingham, Birmingham, United Kingdom., Rendeiro C; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.; Centre for Human Brain Health, University of Birmingham, Birmingham, United Kingdom., Veldhuijzen van Zanten JJCS; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2023 Nov 09; Vol. 10, pp. 1275708. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).
DOI:	10.3389/fnut.2023.1275708
Abstrakt:	Introduction: Mental stress has been identified as a trigger of cardiovascular events. A single episode of stress can induce acute impairments in endothelial function in healthy adults. Importantly, during stressful periods, individuals often resort to unhealthy behaviors, such as increased consumption of high-fat foods, which is also known to negatively impact endothelial function. Therefore, this study examined whether consumption of a high-fat meal would further exacerbate the negative effect of mental stress on vascular function. Methods: In a randomized, counterbalanced, cross- over, postprandial intervention study, 21 healthy males and females ingested a high-fat (56.5 g fat) or a low-fat (11.4 g fat) meal 1.5 h before an 8-min mental stress task (Paced-Auditory-Serial-Addition-Task, PASAT). Plasma triglyceride (TAG) concentration was assessed pre-and post-meal. Forearm blood flow (FBF), blood pressure (BP), and cardiovascular activity were assessed pre-meal at rest and post-meal at rest and during stress. Endothelial function, measured by brachial flow-mediated dilatation (FMD) was assessed pre-meal and 30 and 90 min following mental stress. Results: Plasma TAG concentration was significantly increased following the high-fat meal compared to the low-fat condition. Mental stress induced similar increases in peripheral vasodilation, BP, and cardiovascular activity, and impaired FMD 30 min post-stress, in both conditions. FMD remained significantly impaired 90 min following stress in the high-fat condition only, suggesting that consumption of fat attenuates the recovery of endothelial function following mental stress. Discussion: Given the prevalence of fat consumption during stressful periods among young adults, these findings have important implications for dietary choices to protect the vasculature during periods of stress. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Baynham, Weaver, Rendeiro and Veldhuijzen van Zanten.)
Databáze:	MEDLINE
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