A multi-center prospective study of plant-based nutritional support in adult community-based patients at risk of disease-related malnutrition.

Autor:	Delsoglio M; Research & Innovation, Nutricia Ltd., Trowbridge, United Kingdom., Griffen C; Research & Innovation, Nutricia Ltd., Trowbridge, United Kingdom., Syed R; Preston Hill Surgery, Harrow, United Kingdom., Cookson T; Trowbridge Health Centre, Trowbridge, United Kingdom., Saliba H; Trowbridge Health Centre, Trowbridge, United Kingdom., Vowles A; Trowbridge Health Centre, Trowbridge, United Kingdom., Davies S; West Walk Surgery, Yate, United Kingdom., Willey N; West Walk Surgery, Yate, United Kingdom., Thomas J; West Walk Surgery, Yate, United Kingdom., Millen N; Cowplain Family Practice, Waterlooville, United Kingdom., Odeh N; Cowplain Family Practice, Waterlooville, United Kingdom., Longstaff J; Cowplain Family Practice, Waterlooville, United Kingdom., Westran N; Department of Nutrition and Dietetics, Royal Surrey NHS Foundation Trust, Royal Surrey County Hospital, Guildford, United Kingdom., Allan L; Department of Nutrition and Dietetics, Royal Surrey NHS Foundation Trust, Royal Surrey County Hospital, Guildford, United Kingdom., Offer H; Dietetic Department, Thorpe Health Centre, Norfolk Community Health and Care NHS Trust, Norwich, United Kingdom., Howell C; Dietetic Department, Thorpe Health Centre, Norfolk Community Health and Care NHS Trust, Norwich, United Kingdom., Sanders M; Dietetic Department, Thorpe Health Centre, Norfolk Community Health and Care NHS Trust, Norwich, United Kingdom., Gaffigan K; Dietetic Department, Thorpe Health Centre, Norfolk Community Health and Care NHS Trust, Norwich, United Kingdom., Garrett K; Dietetic Department, Thorpe Health Centre, Norfolk Community Health and Care NHS Trust, Norwich, United Kingdom., Foster S; Nutrition and Dietetic Department, North Tyneside District General Hospital, Tyne and Wear, United Kingdom., Salt A; Nutrition and Dietetic Department, North Tyneside District General Hospital, Tyne and Wear, United Kingdom., Carter E; Nutrition and Dietetic Department, North Tyneside District General Hospital, Tyne and Wear, United Kingdom., Moore S; Nutrition and Dietetic Department, North Tyneside District General Hospital, Tyne and Wear, United Kingdom., Bergin N; Department of Nutrition and Dietetics, Airedale General Hospital, Keighley, West Yorkshire, United Kingdom., Roper J; Warden Lodge Medical Practice, Cheshunt, United Kingdom., Alvarez J; Warden Lodge Medical Practice, Cheshunt, United Kingdom., Voss C; Rowden Medical Partnership, Chippenham, United Kingdom., Connolly T; Rowden Medical Partnership, Chippenham, United Kingdom., MacDonald C; Rowden Medical Partnership, Chippenham, United Kingdom., Thrower T; Rowden Medical Partnership, Chippenham, United Kingdom., Sills D; Nutrition and Dietetics, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom., Baxter J; Department Nutrition and Dietetics, Kings Cross Hospital, Dundee, United Kingdom., Manning R; Department Nutrition and Dietetics, Kings Cross Hospital, Dundee, United Kingdom., Gray L; Dietetics, Victoria Integrated Care Centre, Helensburgh, United Kingdom., Voas K; Dietetic Department, Betsi Cadwaladr University Health Board, Denbighshire, United Kingdom., Richardson S; James Alexander Family Practice, Bransholme South Health Centre, Hull, United Kingdom., Hurren AM; James Alexander Family Practice, Bransholme South Health Centre, Hull, United Kingdom., Murphy D; Honiton Surgery, Honiton, United Kingdom., Blake S; Honiton Surgery, Honiton, United Kingdom., McArdle P; Birmingham Community Nutrition, Birmingham, United Kingdom., Walsh S; Birmingham Community Nutrition, Birmingham, United Kingdom., Booth L; Birmingham Community Nutrition, Birmingham, United Kingdom., Albrich L; Yeovil District Hospitals, Yeovil, United Kingdom., Ashley-Maguire S; Yeovil District Hospitals, Yeovil, United Kingdom., Allison J; Yeovil District Hospitals, Yeovil, United Kingdom., Brook S; Dietetics, Princess Royal Health Centre, Huddersfield, United Kingdom., Capener R; Research & Innovation, Nutricia Ltd., Trowbridge, United Kingdom., Hubbard GP; Research & Innovation, Nutricia Ltd., Trowbridge, United Kingdom., Stratton RJ; Research & Innovation, Nutricia Ltd., Trowbridge, United Kingdom.; Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2023 Nov 10; Vol. 10, pp. 1297624. Date of Electronic Publication: 2023 Nov 10 (Print Publication: 2023).
DOI:	10.3389/fnut.2023.1297624
Abstrakt:	Introduction: There is an emerging need for plant-based, vegan options for patients requiring nutritional support. Methods: Twenty-four adults at risk of malnutrition (age: 59 years (SD 18); Sex: 18 female, 6 male; BMI: 19.0 kg/m 2 (SD 3.3); multiple diagnoses) requiring plant-based nutritional support participated in a multi-center, prospective study of a (vegan suitable) multi-nutrient, ready-to-drink, oral nutritional supplement (ONS) [1.5 kcal/mL; 300 kcal, 12 g protein/200 mL bottle, mean prescription 275 mL/day (SD 115)] alongside dietary advice for 28 days. Compliance, anthropometry, malnutrition risk, dietary intake, appetite, acceptability, gastrointestinal (GI) tolerance, nutritional goal(s), and safety were assessed. Results: Patients required a plant-based ONS due to personal preference/variety (33%), religious/cultural reasons (28%), veganism/reduce animal-derived consumption (17%), environmental/sustainability reasons (17%), and health reasons (5%). Compliance was 94% (SD 16). High risk of malnutrition ('MUST' score ≥ 2) reduced from 20 to 16 patients ( p  = 0.046). Body weight (+0.6 kg (SD 1.2), p  = 0.02), BMI (+0.2 kg/m 2 (SD 0.5), p  = 0.03), total mean energy (+387 kcal/day (SD 416), p  < 0.0001) and protein intake (+14 g/day (SD 39), p  = 0.03), and the number of micronutrients meeting the UK reference nutrient intake (RNI) (7 vs. 14, p  = 0.008) significantly increased. Appetite (Simplified Nutritional Appetite Questionnaire (SNAQ) score; p  = 0.13) was maintained. Most GI symptoms were stable throughout the study ( p  > 0.06) with no serious adverse events related. Discussion: This study highlights that plant-based nutrition support using a vegan-suitable plant-based ONS is highly complied with, improving the nutritional outcomes of patients at risk of malnutrition. Competing Interests: MD, CG, RC, GPH and RJS were employed by Nutricia Ltd. The authors declare that this study received funding from Nutricia Ltd. The funder had the following involvement in the study: study design, data analysis, preparation of the manuscript and decision to publish. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Delsoglio, Griffen, Syed, Cookson, Saliba, Vowles, Davies, Willey, Thomas, Millen, Odeh, Longstaff, Westran, Allan, Offer, Howell, Sanders, Gaffigan, Garrett, Foster, Salt, Carter, Moore, Bergin, Roper, Alvarez, Voss, Connolly, MacDonald, Thrower, Sills, Baxter, Manning, Gray, Voas, Richardson, Hurren, Murphy, Blake, McArdle, Walsh, Booth, Albrich, Ashley-Maguire, Allison, Brook, Capener, Hubbard and Stratton.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu