Cranberry Supplements for Urinary Tract Infection Prophylaxis in Pregnant Women: A Systematic Review of Clinical Trials and Observational Studies on Efficacy, Acceptability, Outcomes Measurement Methods, and Studies' Feasibility.

Autor:	Bolgarina Z; Principles and Practice of Clinical Research, Harvard T.H. Chan School of Public Health, Boston, USA.; Obstetrics and Gynecology, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Gonzalez-Gonzalez LF; Principles and Practice of Clinical Research, Harvard T.H. Chan School of Public Health, Boston, USA., Rodroiguez GV; Principles and Practice of Clinical Research, Harvard T.H. Chan School of Public Health, Boston, USA., Camacho A; Principles and Practice of Clinical Research, Harvard T.H. Chan School of Public Health, Boston, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Oct 09; Vol. 15 (10), pp. e46738. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).
DOI:	10.7759/cureus.46738
Abstrakt:	Cranberry supplements are commonly used to prevent urinary tract infections (UTIs). However, their usefulness is uncertain in pregnant women. We aimed to comprehensively summarize the current knowledge on cranberry supplements' efficacy and acceptability during pregnancy in addition to the outcomes measurement methods and studies' feasibility. To achieve it, we searched PubMed, PMC, and Europe PMC databases plus screened citations followed by critical appraisal of included eligible English-written primary studies that (1) focused on pregnant women supplemented with any cranberry supplements; (2) provided data on cranberry supplements' efficacy, acceptability, outcomes measurement methods, and studies' feasibility; (3) included human subjects; and (4) published worldwide. Two randomized clinical trials (RCTs) and one nested cohort study, including 1156 pregnant women in total, contributed to our analysis. A tendency toward UTI reduction was demonstrated, although the results' validity was impacted by significant juice-induced gastrointestinal intolerance (23%; 44 of 188 subjects). Changing the form of supplementation from cranberry juice to capsules reduced the issue, causing side effects in one of 49 subjects (2%). Nevertheless, both RCTs still experienced significant recruitment and retention problems, which were at 33% and 59% on average, respectively. Newly acquired safety data on 919 more subjects suggests no increased risks of all malformations, vaginal bleeding, and neonatal complications. Investigating cranberry capsules' efficacy as a non-antibacterial option for UTI prevention in pregnant women has become a feasible and important direction with the current advancement in understanding cranberry supplements' actions, recommended doses plus regimens, and their safety in the population. We reviewed the challenges and discovered knowledge gaps and the implementation strategies for future studies. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Bolgarina et al.)
Databáze:	MEDLINE
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